摘要
系统性红斑狼疮是一种自身免疫介导的、以免疫性炎症为突出表现的弥漫性结缔组织病,以血清中出现多种自身抗体和多系统如皮肤、关节、肾脏、神经系统、心脏、肺部等受累为临床特征。据统计,我国系统性红斑狼疮的患病率为70/10万.
To investigate the pathophysiology,screening,diagnosis and treatment of the systemic lupus erythematosus （SLE） in pregnancy complicated with pulmonary hypertension. Retrospective analysis was made of one case of SLE in pregnancy complicated with pulmonary hypertension in Peking University Third Hospital. Literature was reviewed to investigate the pathophysiology,screening,diagnosis and treatment of the SLE in pregnancy complicated with pulmonary hypertension. SLE is an autoimmune mediated diffuse connective tissue disease characterized by immunological inflammation. The incidence of SLE combined with pulmonary hypertension was low,but the risk was high with pregnancy,with a high perinatal mortality rate. Pulmonary hypertension is the leading cause of the death in patients with pregnancy complicated with SLE. This patient was diagnosed with SLE six years before and was hospitalized for 29 weeks of menopause,with fatigue five months and chest congestion one month. Ultrasonic cardiogram showed severe pulmonary hypertension,with pulmonary arterial systolic pressure being 96 mm Hg.After admission,multidisciplinary consultation was organized to draw up a diagnosis and treatment plan.The patient received the treatment of rest,oxygen,blood gas and pulmonary artery pressure monitoring.Considering perioperative pulmonary hypertension crisis likely to occur,pulmonary artery catheter was placed preoperatively. In general anesthesia,the cesarean was performed. After operation,the patient was transferred to the intensive care unit,with the treatment of expanding blood vessels,reducing pulmonary artery pressure,administering anticoagulation and preventing infection. Ten days after operation,the patient was discharged from hospital with smooth condition. Strengthening the management of SLE patients in pregnancy,early detection,and cooperation of multidisciplinary teams can help improve maternal and fetal outcomes. Termination of pregnancy should be offered to the patients with severe pulmonary hypertension. Right cardiac cat
作者
郭晓玥
邵珲
赵扬玉
GUO Xiao-yue;SHAO Hui;ZHAO Yang-yu(Department of Obstetrics and Gynecology-,Peking University Third Hospital,Beijing 100191,China)
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2018年第5期928-931,共4页
Journal of Peking University:Health Sciences
关键词
系统系红斑狼疮
肺动脉高压
妊娠
Systemic lupus erythematosus
Pulmonary arterial hypertension
Pregnancy
