摘要
目的了解影响系统性红斑狼疮(SLE)继发肺动脉高压(PAH)患者预后的因素,并探讨治疗策略。方法对35例SLE继发PAH患者随访2年,观察生存结果,并采用COX回归法对患者的临床资料进行分析,找出对患者预后有显著意义的影响因子。结果35例SLE继发PAH患者,2年内共有12例患者死亡,病死率为34.3%。最终进入回归方程的变量为初诊时肺动脉收缩压值、应用环磷酰胺冲击治疗和感染3项(P值均<0.05)。结论SLE继发重度PAH患者预后恶劣,合并肺部感染者预后不良,每月规则环磷酰胺冲击治疗对延长患者生存期具有积极意义。
Objective To investigate the factors associated with the prognosis of pulmonary hypertension （PAH） secondary to systemic lupus erythematosus （SLE） and to discuss the strategy of treatment. Methods Thirty-five patients with PAH secondary to SLE were followed up for 2 years and their survival was observed. COX regression was employed to analyze the clinical data of patients to search for the factors influencing the prognosis of patients. Results Twelve patients died during the 2 years follow-up, with the mortality being 34.3%. The results of COX regression demonstrated that the PASP value at first visit, intravenous pulse therapy with CTX and pulmonary infection were the factors influencing the survival of patients （all P 〉 0.05）. Conclusion The prognosis of patients with PAH secondary to SLE is poor, especially those complicated with pulmonary infection. Monthly intravenous pulse therapy with cyclophosphomide may benefit the longer survival of patients.
出处
《上海医学》
CAS
CSCD
北大核心
2007年第8期612-614,共3页
Shanghai Medical Journal
基金
上海市重点学科建设项目资助(T0203)
关键词
系统性红斑狼疮
肺动脉高压
环磷酰胺
预后
Systemic lupus erythematosus
Pulmonary hypertension
Cyclophosphomide
Prognosis
