摘要
目的:观察环状混合痔内服方联合生肌玉红膏外用对环状混合痔术后创面愈合及对血清中缺氧诱导因子(HIF)-1α、血管内皮生长因子(VEGF)和基质金属蛋白酶(MMP)-9水平的影响。方法:将110例环状混合痔风热瘀阻证患者随机分为对照组和治疗组各55例。2组患者均行环状混合痔外剥内扎术,配合抗生素预防感染、服用芪蓉润肠口服液等常规措施,治疗组洗净疮面后以生肌玉红膏外涂,以无菌纱布覆盖,服用环状混合痔内服方水煎液。2组连续治疗10天。比较2组的创面恢复情况(创面疼痛、创面渗出、创面肿胀、创面肉芽组织及创面面积)和临床疗效,检测2组血清中的HIF-1α、VEGF和MMP-9水平。结果:术后10天,治疗组总有效率为94.55%,明显高于对照组的80.00%,差异有统计学意义(P<0.05)。2组创面疼痛、渗出、肿胀、肉芽组织及面积评分均较术后1天减少(P<0.01),治疗组各项评分均低于对照组(P<0.01)。2组血清HIF-1α、VEGF和MMP-9水平均较术后1天降低(P<0.01),治疗组3项指标水平均低于对照组(P<0.01)。结论:环状混合痔内服方联合生肌玉红膏外用可促进环状混合痔外剥内扎术后创面的愈合,下调血清中的HIF-1α、VEGF和MMP-9水平可能与其修复作用有关。
Objective：To observe the effect of the oral prescription of circumferential mixed hemorrhoids combined with external application of Shengji Yuhong ointment on the promotion of postoperative wound healing of circumferential mixed hemorrhoids and the levels of hypoxia-inducible factor（HIF）-1α, vascular endothelial growth factor（VEGF） and matrix metalloproteinase（MMP）-9 in serum. Methods： Divided 110 cases of patients with circumferential mixed hemorrhoids of wind-heat stagnation syndrome into the control group and the treatment group randomly,55 cases in each group. Both groups received external dissection and internal ligation for circumferential mixed hemorrhoids coordinating with such routine measures as antibiotics against infection and the oral administration of Qirong Runchang oral liquid,while the treatment group received the external application of Shengji Yuhong ointment after cleaning the wound which was later covered by sterile gauze, and received the decoction of oral prescription of circumferential mixed hemorrhoids. The treatment for both groups lasted for 10 days. Compared the recovery conditions（wound pain, wound exudation,wound swelling,granulation tissue in wound and the area of wound） and the clinical effect of the two groups,and detected the levels of HIF-1α,VEGF and MMP-9 in serum of both groups. Results：On the 10 th day after operation,the total effective rate was 94.55%in the treatment group,being significantly higher than 80.00% in the control group,difference being significant（P〈0.05）. The scores of wound pain,exudation,swelling,granulation tissue and its area in both groups were lower than those on the 1 st day after operation（P〈0.01）,and each score in the treatment group was lower than that in the control group respectively（P〈0.01）. The levels of HIF-1α,VEGF and MMP-9 in serum of both groups were lower than those on the 1 st day after operation（P〈0.01）,and the levels of the three indexes in the treatment group were lower than those in the c
作者
张玉红
虞哲波
ZHANG Yuhong;YU Zhebo
出处
《新中医》
CAS
2018年第9期161-164,共4页
New Chinese Medicine
关键词
环状混合痔
风热瘀阻证
中西医结合疗法
环状混合痔内服方
生肌玉红膏
创面愈合
Circumferential mixed hemorrhoids
Wind-heat stagnation syndrome
Integrated Chinese and western medicine therapy
Oral prescription of circumferential mixed hemorrhoids,
Shengji Yuhong ointment
Wound healing
