摘要
目的观察复方斑蝥注射液对直肠癌术后FOLFOX4化疗患者免疫功能及血清转化生长因子-β_1(TGF-β_1)和C反应蛋白(CRP)表达的影响。方法将98例直肠癌术后患者随机分为2组,对照组49例给予FOLFOX4方案化疗,研究组49例给予复方斑蝥注射液联合FOLFOX4方案治疗,2组均以2周为1个化疗周期,持续治疗3个化疗周期。比较2组治疗后临床疗效,检测2组治疗前后免疫功能指标及血清TGF-β_1、CRP水平。结果治疗后,研究组临床治疗总有效率显著高于对照组(P<0.05);对照组CD3^+、CD4^+、CD8^+、CD4^+/CD8^+和NK细胞水平与治疗前比较差异均无统计学意义(P均>0.05),研究组CD3^+、CD4^+、CD4^+/CD8^+和NK细胞水平均较治疗前显著升高(P均<0.05)而CD8^+较治疗前显著降低(P<0.05),且研究组CD3^+、CD4^+、CD4^+/CD8^+和NK细胞水平均显著高于对照组(P均<0.05),CD8^+水平显著低于对照组(P<0.05);2组血清TGF-β_1和CRP水平均较治疗前显著降低(P均<0.05),且研究组均显著低于对照组(P均<0.05)。结论复方斑蝥注射液联合FOLFOX4方案化疗治疗能明显改善直肠癌术后患者免疫功能,降低血清TGF-β_1和CRP水平,从而阻止肿瘤细胞生长、转移。
Objective It is to observe the effect of Compound Cantharidis Injection on the immune function and the expression of serum transforming growth factor-β1（ TGF-β1） and C reactive protein（ CRP） in postoperative patients with rectal cancer for FOLFOX4 chemotherapy. Methods Ninety-eight cases of patients with rectal cancer after operation were randomly divided into 2 groups. Forty-nine cases in the control group were given FOLFOX4 chemotherapy,and forty-nine patients in the study group were treated with Compound Cantharidin Injection combined with FOLFOX4 regimen. The 2 groups were treated with 1 chemotherapy cycles for 2 weeks,and the treatment lasted for 3 chemotherapy cycles. The clinical curative effect of the 2 groups after treatment was compared. The immune function and serum levels of TGF-β1 and CRP were measured before and after treatment in both groups. Results After treatment,the total effective rate of the study group was significantly higher than that of the control group（ P〈0. 05）. The levels of CD3＋,CD4＋,CD8＋,CD4＋/CD8＋and NK cells in the control group were not significantly different from those before treatment（ P〈0. 05）. The levels of CD3＋,CD4＋,CD4＋/CD8＋and NK cells in the study group were significantly higher than those before treatment（ all P〈0. 05）,while the levels of CD8＋were significantly lower than those before treatment（ P〈0. 05）. The levels of CD3＋,CD4＋,CD4＋/CD8＋and NK cells in the study group were significantly higher than those in the control group（ all P〈0. 05）,while CD8＋was significantly lower than that in the control group（ P〈0. 05）. The serum levels of TGF-β1 and CRP in the2 groups were significantly lower than those before treatment（ all P〈0. 05）,and the study group was significantly lower than the control group（ P〈0. 05）. Conclusion Compound Cantharidin Injection combined with FOLFOX4 chemotherapy can significantly improve the immune function of rectal cancer patients after operation,reduce the leve
作者
管云柱
GUAN Yunzhu(Ningde Municipal Hospital,Ningde 352100,Fujian,China)
出处
《现代中西医结合杂志》
CAS
2018年第27期2986-2989,共4页
Modern Journal of Integrated Traditional Chinese and Western Medicine
