摘要
目的探讨参麦注射液联合长春西汀注射液治疗突发性耳聋的临床疗效。方法选取2016年8月—2018年1月延安大学咸阳医院收治的突发性耳聋患者96例为研究对象,按照随机数字表法分为对照组和治疗组,每组各48例。对照组静脉滴注长春西汀注射液,20 mg加入到生理盐水250 m L中,1次/d。治疗组在对照组治疗基础上静脉滴注参麦注射液,20 m L加入到5%葡萄糖溶液250 m L,1次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组的听力和血液流变学。结果治疗后,对照组和治疗组的总有效率分别为77.08%、91.67%,两组比较差异有统计学意义(P<0.05)。治疗后,两组低频区听阀、高频区听阀、平均纯音听阀均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组听力指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组全血黏度、血浆比黏度、血沉方程K值、红细胞电泳指数、纤维蛋白原均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血液流变学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)结论参麦注射液联合长春西汀注射液治疗突发性耳聋具有较好的临床疗效,可改善听力功能,调节血液流变学指标,安全性较好,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Shenmai Injection combined with Vinpocetine Injection in treatment of sudden deafness. Methods Patients（96 cases） with sudden deafness in Xianyang Hospital of Yan＇an University from August 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 48 cases. Patients in the control group were iv administered with Vinpocetine Injection, 20 mg added into normal saline 250 m L, once daily. Patients in the treatment group were iv administered with Shenmai Injection on the basis of the control group, 20 m L added into 5% glucose solution 250 m L, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and hearing and hemorrheology in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 77.08% and 91.67%, respectively, and there was difference between two groups（P〈 0.05）. After treatment, low frequency area audible valve, high frequency area audible valve, and average pure tone audible valve in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. And the hearing indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈 0.05）. After treatment, blood viscosity, plasma specific viscosity, erythrocyte sedimentation rate equation K, erythrocyte electrophoresis index, and fibrinogen in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈 0.05）. And the hemorrheology indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈 0.05）. Conclusion Shenmai Injection combined with Vinpocetine Injection has clinical curative effect in treatment of sudden deafness, can improve hearing function, and regulate hemorheolo
作者
刘教练
蔡继红
LIU Jiao-lian;CAI Ji-hong(Department of Ear-Nose-Throat,Xianyang Hospital of Yah＇an University,Xianyang 712000,China)
出处
《现代药物与临床》
CAS
2018年第8期2079-2082,共4页
Drugs & Clinic
