摘要
目的探究氟西汀及奥氮平联合治疗对帕金森伴抑郁患者认知及P300影响。方法选取帕金森伴抑郁患者123例,随机分为对照组(n=61)与实验组(n=62),对照组口服氟西汀,实验组在对照组的基础上联合小剂量奥氮平治疗,连续治疗8周。采用HAMD量表、MMSE和Mo CA量表评估2组抑郁及认知,统计2组临床疗效;检测2组P300波潜伏期及波幅。结果与治疗前比较,治疗后2~8周,2组HAMD评分逐渐降低(P<0.01),且实验组治疗后2周及2组治疗后4~8周的HAMD评分低于治疗前(P<0.01),且治疗后2-8周实验组低于对照组(P<0.01);治疗后8周实验组临床总有效率(70.97%)显著高于对照组(32.79%)(P<0.01);治疗后8周2组Mo CA评分及实验组MMSE评分较治疗前升高(P<0.01),且实验组Mo CA及MMSE评分高于对照组(P<0.01);治疗后8周2组P300波潜伏期较治疗前缩短,P300波幅较治疗前有增加(P<0.05或P<0.01),且2组差异显著(P<0.01)。结论以氟西汀联合奥氮平治疗帕金森病伴抑郁患者可改善其抑郁症状,提高认知,调节P300认知电位,临床疗效优于氟西汀单用。
Objective To explore the effect of fluoxetine combined with olanzapine on cognitive function and P300 for parkinson＇s disease patients with depression. Methods A total of 123 cases of parkinson＇s disease patients with depression were selected and divided randomly into control group（n=61）and experiment group（n=62）randomly. Control group were treated with fluoxetine,and experiment group were treated combined with olanzapine,treated for 8 weeks. The depressive state and cognitive function were assessed by HAMD scale,MMSE and Mo CA scale,the clinical efficacy and the changes of P300 incubation and amplitude in two groups were detected. Results Compared with before treatment,during 2-8 weeks after treatment,the HAMD scores decreased gradually;compared with before treatment,the HAMD scores in experiment group after 2 weeks of treatement（P〈0.01）and in control group after 4 weeks of treatmentwere decreased,and which of experiment group was lower than that of control group（P〈0.01）;8 weeks after treatment,the total clinical effective rate of experiment group was 70.97%,which was higher than that 32.79% of control group（P〈0.01）;The Mo CA scores of 2 groups and the MMSE score of experiment group increased compared with before treatemnt 8 weeks after treatment（P〈0.01）,and the Mo CA and MMSE scores of experiment group were higher than that of control group（P〈0.01）;Compared with before treatment,the P300 amplitude of 2 groups 8 weeks after treatment shortened,and the P300 incubation of 2 groups 8 weeks after treatment increased（P〈0.05 or P〈0.01）,and the difference between 2 groups was significant（P〈0.01）. Conclusion Fluoxetine combined with olanzapine can improve the depressive state of parkinson＇s disease with depression patients,increase the cognitive function,adjust the P300 Cognitive potential,the clinical efficacy is superior to fluoxetine alone.
作者
官长富
李德川
李先萍
钟丽
GUAN Changfu;LI Dechuan;LI Xianping(Psychiatry Department,The second people＇s hospital of sichuan neijiang,Neijiang 641100,China)
出处
《国际精神病学杂志》
2018年第4期661-663,共3页
Journal Of International Psychiatry
关键词
帕金森病伴抑郁
氟西汀
奥氮平
抑郁
认知
P300
Parkinson＇ s disease with depression
Fluoxetine
Olanzapine
Depressive
Cognitive
P300
