摘要
目的探讨奥氮平联合氟西汀对双相抑郁症患者的临床效果和不良反应。方法选取2020年1月—2021年1月本院收治的110例双相抑郁症患者为研究对象,按治疗方式将其分成对照组和观察组,每组55例。其中,对照组应用奥氮平治疗,观察组应用奥氮平联合氟西汀治疗,两组疗程为期2个月。对比两组患者的治疗效果、治疗前后的抑郁和焦虑评分以及不良反应。结果观察组治疗后的临床有效率明显优于对照组,差异有统计学意义(P=0.038)。两组患者在治疗2个月后的抑郁症和焦虑症得分较治疗之前均有下降,而观察组较对照组下降更明显,差异有统计学意义(P<0.001)。对照组不良反应发生率高于观察组,差异有统计学意义(P<0.001)。结论双相抑郁的治疗中应用氟西汀联合奥氮平治疗效果明显,可有效缓解患者的情绪,减少不良反应,非常值得临床推广应用。
Objective To explore clinical effect and adverse reactions of olanzapine combined with fluoxetine for patients with bipolar depression.Methods The paper chose 110 patients with bipolar depression admitted to a certain hospital from January 2020 to January 2021,and divided them into two groups according to treatment methods.55 cases in control group were treated with olanzapine,while 55 cases in observation group with olanzapine plus fluoxetine.Treatment course for both groups was 2 months.Curative effect,depression and anxiety scores,adverse reactions were compared and analyzed between two groups before and after treatment.Results Clinical effect of observation group after treatment(94.54%)was significantly better than control group(81.81%),with significant difference(P=0.038).Depression and anxiety scores of observation group were lower after 2 months than before treatment,observation group showed more significant decrease than control group(P<0.01).Total incidence of adverse reactions in observation group was 14.54%,higher than 47.45%in in control group,(P<0.001).Conclusion Fluoxetine combined with olanzapine can achieve significant curative effect in treatment of bipolar depression,can effectively alleviate emotions and reduce adverse reactions of patients,which is highly worthy of clinical promotion and application.
作者
周贵
ZHOU Gui(Guigang Yukang Mental Hospital,Guigang,Guangxi 537100)
出处
《智慧健康》
2024年第12期134-136,共3页
Smart Healthcare
关键词
双相抑郁
氟西汀
奥氮平
治疗效果
安全性
Bipolar depression
Fluoxetine
Olanzapine
Curative effect
Safety
