摘要
目的分析未足月胎膜早破发生的风险因素。方法选取2015年7月~2017年2月在我院行产检的未足月胎膜早破患者105例作为研究组,另选取同期未发生胎膜早破的健康孕妇100例作为对照组,比较两组的一般临床资料、白介素-6(IL-6)、IL-8、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、平均血小板容积(MPV)及降钙素原(PCT),采用Logistic回归分析未足月胎膜早破发生的影响因素,并采用森林图显示各个指标效应大小。结果与对照组比较,研究组的IL-6、IL-8、TNF-α、CRP、MVP和PCT均显著升高,差异均有统计学意义(P<0.05);多因素回归分析结果显示,外周血IL-6、IL-8、TNF-α、CRP、MVP及PCT的水平与未足月胎膜早破的发生有显著相关性(P<0.05)。结论外周血IL-6、IL-8、TNF-α、CRP、MVP和PCT可用于预测未足月胎膜早破的风险,具有一定的临床诊断价值。
Objective To analyze the risk factors of preterm premature rupture of membranes（PPROM）. Methods A total of 105 PPROM patients who were examined in our hospital from July 2015 to February 2017 were selected as the study group. Meanwhile, 100 healthy pregnant women without premature rupture of membranes during the same period were chosen as the control group. The general clinical data, interleukin-6（IL-6）, IL-8, tumor necrosis factor-α（TNF-α）, C-reactive protein（CRP）, mean platelet volume（MPV）, and procalcitonin（PCT） were compared in the two groups.The Logistic regression analysis was used to determine the factors affecting PPROM and the strengthen of effect of each index was demonstrated using the forest map. Results Compared with the control group, the levels of IL-6, IL-8, TNF-α, CRP, MVP, and PCT were all significantly increased in the study group, with a statistical difference（P〈0.05）. Multivariate regression analysis showed that the levels of IL-6, IL-8, TNF-α, CRP, MVP and PCT in peripheral blood were significantly associated with the occurrence of PPROM, with a statistical difference（P〈0.05）. Conclusion The levels of IL-6, IL-8, TNF-α, CRP,MVP and PCT in peripheral blood can be used to predict the risk of PPROM, which has certain clinical diagnostic value.
作者
林方
LIN Fang(Department of Gyneeology and Obstetries,Sihui People＇s Hospital,Guangdong Provinee,Sihui 526200,China)
出处
《中国当代医药》
2018年第23期121-123,共3页
China Modern Medicine
关键词
未足月胎膜早破
风险模型建立
白介素
C反应蛋白
Preterm premature rupture of membrane
Risk model establishment
Interleukin
C-reactive protein
