摘要
目的探讨联合检测PPROM孕妇PCT、IL-6、CRP水平的变化在早期诊断宫内感染、发现绒毛膜羊膜炎以及新生儿败血症临床价值。方法选择PPROM孕妇100例作为研究组,同期同孕周的正常孕妇80例作为对照组,检测两组孕妇外周血、分娩时脐血PCT、IL-6、CRP水平;PPROM孕妇分娩后对胎盘胎膜行病理学检查,追踪新生儿感染情况。结果研究组孕妇外周血中PCT、IL-6、CRP表达均明显高于对照组,差异有统计学意义(P<0.01);研究组中有组织学绒毛膜羊膜炎63例,无绒毛膜羊膜炎37例,两组孕妇外周血PCT、IL-6及CRP浓度比较差异均有统计学意义(P<0.01),但非绒毛膜羊膜炎组与对照组比较差异无统计学意义(P>0.05)。PCT、IL-6、CRP各自诊断绒毛膜羊膜炎的敏感性一般,特异性、阳性预测值及阴性预测值均较低,但三者同时阳性诊断绒毛膜羊膜炎的敏感性、特异性及阳性预测值分别为65.08%、94.59%、95.35%。脐血PCT、IL-6、CRP水平在败血症新生儿中显著升高,与新生儿肺炎组、非感染组及对照组新生儿比较差异均有统计学意义(P<0.01)。结论 PPROM孕妇外周血中PCT、IL-6、CRP浓度升高,三者同时阳性预测绒毛膜羊膜炎的价值高,脐血中PCT、IL-6、CRP水平有利于早期诊断新生儿败血症情况。
Objective To explore the clinical value of joint detection of procalcitonin （PCT）, interleukin-6 （IL-6）, and C-reactive protein in early diagnosis of intrauterine infection, chorioamnionitis, and neonatal septicemia among the pregnant women with preterm premature rupture of fetal membrane （PPROM） . Methods One hundred PPROM pregnant women were selected as study group, eighty normal pregnant women during the same gestational week were selected as control group. The levels of PCT, IL-6, and CRP in peripheral blood and umbilical cord blood at the time of birth in the two groups were detected. Pathological examination of placenta and fetal membrane were performed among PPROM pregnant women after delivery; neonatal infection status was traced. Results The expression levels of PCT, IL-6, and CRP in peripheral blood in study group were statistically significantly higher than those in control group （P〈0. 01 ） . In study group, 63 pregnant women were diagnosed as histological chorioamnionitis, and 37 pregnant women were not diagnosed as histological chorioamnionitis, there were statistically significant differences in the expression levels of PCT, IL-6, and CRP in peripheral blood between the two groups （P〈0. 01 ）, but there was no statistically significant difference between non-chorioamnionitis group and control group （P〉0. 05 ） . The sen- sitivities of PCT, IL-6, and CRP in diagnosis of chorioamnionitis were general, the specificities, positive predictive values, and negative predictive values were low. The sensitivity, specificity, and positive predictive value of joint detection of PCT, IL-6, and CRP in diagnosis of chorioamnionitis were 65.08%, 94. 59% , and 95. 35%., respectively. The levels of PCT, IL-6, and CRP in umbilical cord blood of neo-nates with septicemia increased significantly, compared with neonatal pneumonia group, non-infection group, and control group, there were statistically significant differences （ P〈0.01 ） . Conclusion The levels of PCT, IL-6, and CRP in peri
出处
《中国妇幼保健》
CAS
2016年第17期3471-3474,共4页
Maternal and Child Health Care of China
关键词
未足月胎膜早破
降钙素原
白介素-6
C-反应蛋白
绒毛膜羊膜炎
新生儿败血症
Preterm premature rupture of fetal membrane
Procalcitonin
Interleukin-6
C-reactive protein
Chorioamnionitis
Neonatal septicemia
