摘要
目的本研究回顾性分析供/患者造血干细胞采集动员后第1天、采集当日白细胞计数(WBC)对采集物中CD34浓度的影响,以前瞻性地根据患者个体情况制定采集方法。方法选择2016年8月至2017年12月在我院行造血干细胞采集术的85例供/患者作为研究对象,将供/患者注射集落刺激因子剂后第1天、采集当天的WBC计数分为10×109/L<WBC≤20×109/L,20×109/L<WBC≤30×109/L,WBC>30×109/L 3组,分析每组供/患者注射动员剂后第1天以及采集当天的WBC与采集物中CD34细胞浓度之间的关系。结果注射动员剂后第1天的供/患者第1组与第2,3组采集物中CD34浓度有统计学意义(P<0.05);第2组与第3组比较差异无统计学意义(P>0.05)。采集当日供/患者白细胞计数第1组,第2组与第3组采集物中CD34浓度有统计学意义(P<0.05)。采集当日WBC>30×109/L供/患者采集物中CD34质量最高。结论医护人员在动员采集干细胞之前,通过评判不同阶段供/患者WBC的值,可制订不同的动员方案以及采集方法,以达到最大化的采集效果,提高采集成功率。
Objective To prospectively developed a collection method based on individual patient condition,the effect of white blood cell count（ WBC） on day 1 after and that very day of hematopoietic stem cell collecting mobilization of donor/patient on the concentration of CD34 were retrospectively analyzed. Methods To analyzed the relation between the WBC on day 1 after and that very day of the administration of mobilization agent of donor/patient,85 cases of donors/patients who underwent hematopoietic stem cell collection in our hospital from August 2016 to December 2017 were observed. The WBC count on the first day and the day of collection after the injection of the colony stimulating agent was divided into 10 × 10^9/L〈 WBC≤20 × 10^9/L,20× 10^9/L WBC≤30 × 10^9/L,WBC 〉30 × 10^9/L,a total of 3 groups. Results The difference of concentration of CD34 between the first group and the2 nd,3 rd group of the donor/patient on the first day after injection of mobilization agent was statistically significant（ P〈0. 05）. The difference between group 2 and group 3 had no statistical significance（ P〈0. 05）. The concentration of CD34 in the first group,the second group and the third group of the donor/patient white blood cell counts on the day of collection was statistically significant（ P〈0. 05）. The quality of CD34 was highest in the donor/patient collections with WBC〉 30 × 10^9/L on the day of collection. Conclusion Medical staff could make different mobilization schemes and methods by judging the WBC value of donors/patients in different stages before mobilizing and collecting stem cells to maximize the collection effect and improve the success rate of collection.
作者
王文
黄晓兵
WANG Wen;HUANG Xiao-bing
出处
《护理实践与研究》
2018年第16期63-65,共3页
Nursing Practice and Research
基金
四川省卫生厅适宜技术推广项目(100467)
关键词
供/患者
外周造血干细胞采集术
效果
Donor/patient
Peripheral blood stem cell collection
Effect
