摘要
目的回顾性分析非霍奇金淋巴瘤患者自体外周造血干细胞动员采集过程中的影响因素。方法 2014年1月至2016年8月,共有48例非霍奇金淋巴瘤患者在该院血液科行自体外周造血干细胞动员采集,对患者的年龄、性别、疾病分期、诊断时是否骨髓侵犯、化疗次数及病程中是否复发等因素进行回顾性分析。结果 37例患者(77.10%)干细胞动员采集成功,其成功率受疾病诊断到干细胞动员采集的间隔时间、化疗次数、前期化疗(包含氟达拉滨)、复发,以及采集干细胞前的白细胞及血小板水平的影响。结论拟行自体外周造血干细胞的非霍奇金淋巴瘤患者,前期化疗次数不宜多,动员采集要尽早,尽量避免使用可能损伤干细胞的药物,需同时关注患者外周血白细胞和血小板水平,来确定动员采集时机。
Objective To retrospectively analyze the influence factors during autologous peripheral blood stem cell（PBSC）mobilization and collection process in the patients with non-Hodgkin′s lymphoma（NHL）.Methods Forty-eight patients with NHL in our hospital from January 2014 to August 2016 underwent PBPC mobilization and collection.The factors of age,sex,disease stage,bone marrow involvement at diagnosis,chemotherapy frequency,relapse and so on were analyzed retrospectively.Results PBSC mobilization and collection was successful in 37cases（77.10%）.The success rate was affected by the time from diagnosis to mobilization（P=0.038）,chemotherapy courses（P=0.016）,prior chemotherapy including fludarabine（P=0.049）,relapse（P=0.033）,and the levels of white blood cell（P=0.014）and platelet（P〈0.01）before stem cells collection.Conclusion For the patients planning to receive autologous peripheral blood stem cell transplantation,many times of prior chemotherapy are unfavorable,mobilization and collection should be taken as early as possible,chemotherapeutic agents which possibly injure stem cells should be avoided,it is needed to simultaneously pay attention to peripheral blood WBC and platelet level for determining the collection timing.
出处
《重庆医学》
CAS
北大核心
2017年第24期3328-3331,共4页
Chongqing medicine
基金
国家自然科学基金青年基金项目(81100358)
重庆市卫生和计划生育委员会医学科研面上项目(2016MSXM013)
关键词
淋巴瘤
非霍奇金
造血干细胞
外周血干细胞移植
因素分析
统计学
lymphoma
non-hodgkin
hematopoietic stem cells
peripheral blood stem cell transplantation
factor analysis
statistical
