摘要
目的探讨γ-干扰素释放试验(IGRAs)在结核病和高危人群中的诊断价值。方法采用单中心回顾性研究,选取2015年1月至2016年12月诊治并行IGRAs的120例结核病和高危人群作为研究对象,分为肺结核组(A组,40例)、结核性胸膜炎组(B组,40例)和高危人群组(C组,40例),另纳入40例健康体检者为健康对照组(D组)。详细记录病史、基本资料、实验室指标及外周血IGRAs结果。结果 A组、B组、C组及D组IGRAs的阳性率依次为90.00%(36/40),70.00%(28/40),45.00%(18/40)和5.00%(2/40),组间比较,差异均有统计学意义(P<0.05);单因素分析显示,结核病患者中IGRAs阴性者,年龄偏大,多为男性,症状持续时间更长,结核性胸膜炎比例更高;多因素逻辑回归分析显示,年龄>60岁、症状持续时间>1个月和结核性胸膜炎是IGRAs阴性的独立危险因素。结论 IGRAs对于结核病尤其是肺结核有较高的诊断价值。在分析IGRAs时,应充分考虑年龄、症状持续时间及发病部位等多种因素的影响。
Objective To investigate the diagnostic value on tuberculosis（ TB） and high-risk population by interferon-gamma releases assays（ IGRAs）.Methods Totally 120 cases including TB and high-risk population diagnosed by IGRAs and treated in our hospital from January 2015 to December 2016 were selected and analyzed by single-center retrospective study.The cases were divided into pulmonary TB group（ group A,40 cases）,tuberculous pleurisy group（ group B,40 cases） and high-risk population group（ group C,40 cases）.Another 40 medical examination people were selected as health the control group（ group D）.The history,basic data,laboratory index and peripheral blood IGRAs were recorded in details.Results The IGRAs positive rate of group A,B,C and D were 90.00%（ 36/40）,70.00%（ 28/40）,45.00%（ 18/40） and 5.00%（ 2/40）,respectively,and the difference among the 4 groups was statistically significant（ P〈0.05）.The single factor analysis showed that IGRAs negative patients were older,mostly male,with longer duration of symptoms and higher proportions of tuberculous pleurisy.Logistic regression analysis showed that age above 60 years old,duration of symptoms over 1 month and tuberculous pleurisy were independent risk factors for negative IGRAs.Conclusion IGRAs has high diagnostic value on TB,especially the pulmonary TB.Some factors such as age,duration of symptoms and side of disease should be considered when analyzing IGRAs.
作者
郭林旺
钟山
Guo Linwang,Zhong Shan(Haikou People＇s Hospital,Haikou,Hainan,China 57119)
出处
《中国药业》
CAS
2018年第16期74-76,共3页
China Pharmaceuticals
关键词
Γ-干扰素释放试验
肺结核
结核性胸膜炎
高危人群
诊断价值
interferon - gamma releases assays
pulmonary tuberculosis
tuberculous pleurisy
high - risk population
diagnostic value
