摘要
越来越多的证据表明,不可控制的炎症与肿瘤发生、发展有着密切的关系,其中慢性炎症可能在包括膀胱癌在内的各种恶性肿瘤中发挥关键作用。膀胱癌是泌尿系统最常见的恶性肿瘤,对于非肌层浸润性膀胱癌经尿道膀胱肿瘤切除术仍是主要手段,但其术后易复发,复发后恶性度逐渐增加,故术后需辅助性药物治疗,降低其复发与进展。如今免疫治疗成为研究热点,并取得较好效果。本文就诱发膀胱癌的常见慢性炎症因素及其免疫治疗相关研究做一简述。
More and more evidence shows that uncontrollable inflammation has closely associated with tumorigenesis and development. Chronic inflammation may play a key role in various malignant tumors including bladder cancer. Bladder cancer is the most common malignant tumor of the urinary system. For non-muscle-invasive bladder cancer,the main method is still transurethral resection of bladder tumors,but its recurrence after surgery,the degree of malignancy after recurrence is gradually increased,so the need for postoperative adjuvant drug treatment reduces its recurrence and progression. Nowdays,immunotherapy has become a research hotspot and has achieved good effects. This article briefly describes the common chronic inflammation factors that induce bladder cancer and the related progression on immunotherapy.
作者
孙祖刚
王哲
陈怀安
刘硕
苗文隆
SUN Zugang;WANG Zhe;CHEN Huaian;LIU Shuo;MIAO Wenlong(Graduate Faculty,Hebei North University,Zhangjiakou 075000,China;Department of Urology,The First Affiliated Hospital of Hebei North University)
出处
《实用肿瘤学杂志》
CAS
2018年第4期357-361,共5页
Practical Oncology Journal
基金
2017年政府资助临床医学优秀人才培养和基础课题研究项目(冀财社[2017]46号)
关键词
膀胱癌
慢性炎症
诱发因素
免疫治疗
Bladder cancer
Chronic inflammation
Inducing factors
Immunotherapy
