摘要
目的探讨COX-2和Survivin蛋白在胃癌中的表达及临床意义。方法采用免疫组织化学sP法检测76例胃癌和13例正常胃黏膜中COX-2和survivin蛋白的表达，分析二者与胃癌临床病理特征的关系。结果COX-2和Survivin蛋白在胃癌组织中阳性表达率分别为80．26％和77．63％，均显著高于正常胃黏膜组织（P〈0．01）。COX-2蛋白在胃癌中阳性表达与性别、年龄、分化程度、浆膜侵犯等因素无关（P〉0．05），但与淋巴转移、TNM分期密切相关（P〈0．05）。Survivin蛋白在胃癌中的阳性表达与性别、年龄无关（P〉0．05），但与肿瘤分化程度、浆膜侵犯、淋巴结转移、TNM分期密切相关（P〈0．05）。胃癌中COX-2和Survivin蛋白阳性表达呈正相关性（P〈0．05）。结论COX-2和Survivin蛋白在胃癌组织中高表达，可能在胃癌发生发展中起重要作用；COX-2和Survivin蛋白在胃癌中表达呈正相关。联合检测COX-2和Survivin蛋白可作为反映胃癌生物学行为和判断预后的有效指标之一。
Objective To investigate the expression and clinical significance of COX-2 and Survivin protein in gastric carcinoma. Methods In 76 gastric carcinoma specimen and 13 normal mucosa gastric specimen,the exprssion of COX-2 and Survivin protein were detectede by immunohistochemistry SP. The relationship between expression of COX-2 and Survivin protein and clinical pathological parameter were analyzed, also the relationship between COX-2 and Survivin protein. Results The positive expression rate of COX-2 and Survivin protein was 80.26% and 77.63% , and higher t.han those in normal gastric tissues （P 〈 0.01 ）. The positive expression of COX-2 protein was negatively related to gen- der, age, cellular differentiation, serosa infiltration （P 〉 0.05 ） , but associated with lymph node and TNM stage （P 〈 0. 05）. The positive expression of Sm＇vivin protein was not related to gender, age （P 〉 0..05 ）, but associated with cellnlar differentiation, serosa infiltration, lymph node metastasis and TNM stage （ P 〈 0.05 ）. The expression of COX-2 protein was positively correlated with Survivin protein （P 〈 0.01 ）. Conclusion COX-2, Survivin protein play an important role in the genesis and development of gastric carcinoma. The expression of Survivin and COX-2 protein may be the index of prognostic evaluation and determination of biological behavior in gastric carcinoma.
出处
《中国基层医药》
CAS
2009年第12期2156-2158,共3页
Chinese Journal of Primary Medicine and Pharmacy
