摘要
目的探讨凋亡抑制基因Survivin在乳腺癌组织、癌旁乳腺组织中的表达及意义。方法用免疫组化S-P法检测80例乳腺癌组织、20例癌旁乳腺组织中Survivin的表达,分析不同病理组织间的表达关系。结果Survivin基因在乳腺癌中阳性表达率为68.75%(55/80),明显高于癌旁腺体组织(15%、3/20)的表达(P<0.05)。结论Survivin基因的抑制凋亡作用可能在乳腺癌的发生、发展过程中起重要作用,提示其可作为乳腺癌一种新的预后判断指标。
To investigate the expression of anti-apoptosis gene Survivin in breast cancer tissue,paracarcinoma breast tissue, and its significance. The expression of Survivin in 80 case breast cancer tissues and 20 case pericarcinomatous breast tissues were detect by immunohistochemistry S-P way, the relationship among them was analysed. Positive expression rate of Survivin gene was 68.75%(55/80) in breast cancer tissues, obviously higher than in paracarcinoma breast tissues(15%, 3/20) (P <0.05). [Conclusions] The anti-apoptosis effect of Survivin gene may be important in the occurrence and advancement of breast cancer, infering that it can be a new indicator of prognostic and judgement in breast cancer.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第6期815-817,共3页
China Journal of Modern Medicine
