摘要
目的探讨Survivin在胃癌前病变与胃癌中的表达,并了解其表达与Hp感染的相关性。方法Survivin检测采用免疫组化染色;Hp检测采用快速尿素酶试验与Giemsa染色。结果30例胃癌前病变中有10例Survivin呈阳性(33.3%),30例胃癌有22例Survivin呈阳性(73.3%),两者比较差异有显著性(P<0.05)。Hp在两种组织中差异无显著性(P>0.5)。38例Hp阳性中有25例Survivin表达阳性(65.8%),13例阴性;22例Hp阴性中只有7例阳性(31.9%),15例呈阴性反应;两者相关比较差异有显著性(P<0.05)。结论Sur-vivin表达在胃癌前病变与胃癌中均有表达,随着病变加重,表达逐渐增加;Survivin表达与Hp感染相关。
[Objective] To observe expression of survivin in gastric precancerous lesions （PGL） and gastric cancer, and its correlation with helicobactor pylori（Hp） infection. [Method] Sixty cases with pathologically confrrmed GPL and gastric cancer were studied. The expression of survivin was determined by immunohistochemistry. Helicobactor pylori infection was determined by rapid urease test and giemasa staining. [Results] The positive expression rate of survivin in gastric cancer （73.3%） was significantly higher than that of PGL（33.3%）, demonstrated the obvious difference （P 〈0.05）. The rates of Hp infection in GPL and gastric cancer were 70%, 58.6%, respectively, no statistical difference （P 〉0.5） found. The positive expression rate of survivin in Hp postive infection （25/38, 65.8%） was higher than that of in Hp negative infection （7/20, 31.9%）. There were significant differences （P 〈0.05） between them. [Conclusion] Survivin is expressed in GPL and gastric cancer and expression of survivin is increasing with aggravation of pathological changes. There is obvious correlationship between expression of survivin and Hp infection.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第14期2152-2153,2156,共3页
China Journal of Modern Medicine
