摘要
目的探讨参麦注射液联合丁苯酞氯化钠注射液治疗急性脑梗死的临床疗效。方法选取2016年1月—2018年1月解放军第二五五医院收治的急性脑梗死患者140例为研究对象,根据随机区组设计法将患者分为对照组和治疗组,每组各70例。对照组静脉滴注丁苯酞氯化钠注射液,25 mg/次,2次/d。治疗组在对照组治疗基础上静脉滴注参麦注射液,50 mL加入到5%葡萄糖溶液250 mL中,1次/d。两组患者均连续治疗14 d。观察两组的临床疗效,比较两组的神经功能、生活能力、凝血功能指标、血清炎性指标。结果治疗后,对照组和治疗组的总有效率分别为71.4%、90.0%,两组比较差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin评分(m RS)均显著降低,Barthel指数显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组神经功能和生活能力指标明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组活化部分凝血酶时间(APTT)、凝血酶原时间(PT)均显著升高,纤维蛋白原(FIB)、血小板计数(PLT)均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组FIB、PLT明显高于对照组,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-18(IL-18)、S100β蛋白(S100β)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血清炎性指标水平明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论参麦注射液联合丁苯酞氯化钠注射液治疗急性脑梗死具有较好的临床疗效,可改善患者神经功能和血清炎性指标,提高生活能力,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Shenmai Injection combined with Butylphthalide and Sodium Chloride Injection in treatment of acute cerebral infarction. Methods Patients（140 cases） with acute cerebral infarction in the No. 255 Hospital of Chinese People＇s Liberation Army from January 2016 to January 2018 were randomly divided into control and treatment groups, and each group had 70 cases. Patients in the control group were iv administered with Butylphthalide and Sodium Chloride Injection, 25 mg/time, twice daily. Patients in the treatment group were iv administered with Shenmai Injection on the basis of the control group, 50 mL added into 5% glucose solution 250 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and neurological function, life ability, coagulation function indexes, and serum inflammatory indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 71.4% and 90.0%, respectively, and there was difference between two groups（P〈0.05）. After treatment, NIHSS scores and MRS in two groups were significantly decreased, but Barthel indexes in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, APTT and PT in two groups were significantly decreased, but FIB and PLT in two groups were significantly increased, and the difference was statistically significant in the same group（P〈0.05）. And FIB and PLT in the treatment group were significantly higher than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the levels of TNF-α, IL-18, and S100β in two groups were significantly decreased, and the difference was statistically significant
作者
张飞飞
孙妍
张丽
董功巧
陈智永
刘冰
ZHANG Fei-fei;SUN Yan;ZHANG Li;DONG Qiao-li;CHEN Zhi-yong;LIU Bing(Department of Neurology,No.255 Hospital of Chinese People’s Liberation Army,Tangshan 063000,Chin)
出处
《现代药物与临床》
CAS
2018年第7期1635-1639,共5页
Drugs & Clinic
关键词
参麦注射液
丁苯酞氯化钠注射液
急性脑梗死
神经功能
生活能力
凝血功能
炎性指标
Shenmai Injection
Butylphthalide and Sodium Chloride Injection
acute cerebral infarction
neurological function
life ability
coagulation function index
serum inflammatory index
