摘要
目的：探究健脾化瘀方联合辛伐他汀对脂肪肝合并高脂血症患者肝功能、血脂及血液流变学的影响,为患者的临床治疗提供参考。方法：选取2017年1月—2017年9月收治的脂肪肝合并高血脂患者60例治疗情况,采用随机数表法将患者分为观察组和对照组各30例,观察组患者采用健脾化瘀方联合辛伐他汀进行治疗,对照组患者仅采取辛伐他汀进行治疗,分析两组患者治疗前后肝功能、血脂、血液流变学改变情况以及患者治疗后生活质量评分和治疗效果。结果：观察组患者在经过治疗后治疗的总有效率为96.7%,明显高于对照组,两组数据差异具有统计学意义（u=5.8165,P=0.0003）,观察组患者在治疗前TC、TG、HDL-C、LDL-C以及ALT、CGT、CHE水平与对照组比较,两组数据差异无统计学意义（P〉0.05）,在经过治疗后,观察组患者TC、TG、LDL-C以及ALT、CGT、CHE水平分别为（4.3±0.7）mmol/L、（1.5±0.5）mmol/L、（3.5±0.5）mmol/L、（47.8±12.7）U/L、（21.6±7.6）IU/L、（5095.7±183.5）U/L,明显低于对照组（t=7.2136、1.7108、2.1039、2.4571、2.7612、22.4905,P=0.0000、0.0015、0.0397、0.0170、0.0077、0.0000）,HDL-C水平为（1.4±0.4）mmol/L,明显高于对照组（t=2.1909,P=0.0325）,并且观察组患者在经过治疗后进行血液流变学指标检测显示,患者全血高切黏度、全血低切黏度、全血中切黏度、血浆黏度、红细胞聚集指数、红细胞变形指数以及红细胞压积等各项水平分别为（5.1±1.2）m Pa/s、（7.7±2.6）m Pa/s、（6.2±1.4）m Pa/s、（1.3±0.3）m Pa/s、2.5%±0.7%、0.7%±0.1%、46.7%±9.2%,均明显低于对照组,二者数据差异具有统计学意义（t=3.2675、3.0686、5.0498、7.7460、2.0610、4.8990、2.4754,P=0.0018、0.0033、0.0000、0.0000、0.0438、0.0000、0.0162）。观察组患者经过治疗后的生活质量评分显示,生理功能评分、感知功能评分、情绪功能评分以及社会功能评分�
Objective：To investigate the effect of Jianpi Huayu Decoction combined with simvastatin on liver function,blood lipid and hemorheology in patients with fatty liver complicated with hyperlipidemia,and to provide reference for the clinical treatment of patients. Methods：We reviewed the treatment of 60 cases of fatty liver with hyperlipidemia treated in our hospital from January 2017 to September 2017,the patients were divided into observation group and control group（30 cases）by random number table method. The patients in the observation group were treated with Jianpi Huayu Decoction combined with simvastatin. The control group was treated with simvastatin only. The changes of liver function,blood lipid and hemorheology,and the quality of life score were analyzed before and after treatment. Results：The total effective rate was 96.7% after treatment,and the difference was statistically significant（u=5.8165,P=0.0003）. The patients in the observation group were significantly higher than those in the control group before treatment TC,TG,HDL-C,LDL-C,ALT,CGT and CHE were significantly higher than those in the control group（P 0.05）. After treatment,the levels of TC,TG,LDL-C and ALT,CGT and CHE were（4.3±0.7）mmol/L,（1.5±0.5）mmol/L,（3.5±0.5）mmol/L,（47.8±12.7）U/L,（21.6±7.6）IU/L and（5095.7±183.5）U/L,respectively（t= 7.2136,1.7108,2.1039,2.4571,2.7612,22.4905,P=0.0000,0.0015,0.0397,0.0170,0.0077,0.0000）,the level of HDL-C was（1.4±0.4）mmol/L,which was significantly higher than that of the control group（t=2.1909,P=0.0325）. The hemorheological indexes of the patients in the observation group showed that the blood viscosity,blood viscosity,whole blood cut viscosity,plasma viscosity,erythrocyte aggregation index,erythrocyte deformation index and hematocrit and other levels were（5.1±1.2）m Pa/s,（7.7±2.6）m Pa/s,（6.2±1.4）m Pa/s,（1.3±0.3）m Pa/s,（2.5%±0.7%）,（0.7%±0.1%）,（46.7%±9.2%）and the difference was statistically significant（t=3.2675,3.0686
作者
彭雪萍
曾永青
吴虹
PENG Xueping;ZENG Yongqing;WU Hong(The Third People＇s Hospital of Huizhou,Huizhou 516000,Guangdong,China)
出处
《辽宁中医药大学学报》
CAS
2018年第8期162-165,共4页
Journal of Liaoning University of Traditional Chinese Medicine
基金
惠州市科技计划项目(2017Y124)
关键词
健脾化瘀方
辛伐他汀
脂肪肝
高血脂
Jianpi Huayu Decoction
simvastatin
fatty liver
high blood lipids
