摘要
目的:探讨黄酮类成分木犀草素对高脂饮食诱导的肥胖小鼠模型的胰岛素抵抗的影响。方法:30只C57BL/6J小鼠分正常饮食对照组(10只),高脂膳食组(对照组,10只)和高脂膳食加2%木犀草素组(木犀草素组,10只),干预16周,观察体重、血脂水平、血糖、胰岛素敏感性及胰岛素水平的变化。结果:小鼠在给予高脂膳食16周后,体重水平、血脂水平、血糖水平、胰岛素水平显著高于木犀草素组,胰岛素敏感性显著下降,与木犀草素组比较,P<0.05或P<0.01。而木犀草素组则可显著抑制体重、血脂、血糖及胰岛素水平的升高,与胰岛素敏感性未见明显下降,与正常对照组比较,P>0.05。结论:木犀草素可预防高脂膳食诱导的胰岛素抵抗。
Objective： To explore the effect of flavonoids chemical Luteolin to the insulin resistance induced by the high fat diet in the mice.Methods： 30 mice were divided into three groups,the normal chow group（10 mice）,the high fat diet group（10 mice）,the high fat diet＋2%Luteolin group,the intervention time is 16 weeks.The body weight,lipids levels,blood glucose level,insulin sensitivity and the variation of insulin were detected.Results： After administration of 16 weeks high fat diet,the body weight,the blood glucose level,the lipids level and the insulin level were significantly increased in mice of the high fat diet group,and the insulin sensitivity were decreased,compared with the Luteolin group,P〈0.05 or P〈0.01.In the Luteolin group,the body,lipids level,blood glucose level and insulin level increased slightly when compared with the control group,but no significantly difference exist,P 〉0.05.Conclusion： Luteolin can prevents the mice insulin resistance induced by high fat diet.
出处
《现代生物医学进展》
CAS
2012年第14期2651-2653,2671,共4页
Progress in Modern Biomedicine
关键词
木犀草素
高脂膳食
胰岛素抵抗
血糖
胰岛素敏感性
Luteolin； High fat diet； Insulin resistance； Blood glucose level； Insulin sensitivity
