摘要
目的:观察重组牛碱性成纤维细胞生长因子(rb FGF)联合负压引流促进Ⅱ度烧伤患者创面愈合临床效果。方法:前瞻性研究收治的Ⅱ度烧伤64例,随机将患者分为观察组和对照组,每组32例,对照组采用负压引流治疗,观察组采用rb FGF联合负压引流治疗。比较两组患者治疗后的创面愈合临床效果及瘢痕情况。结果:观察组治疗后浅Ⅱ度、深Ⅱ度烧伤肉芽生长明显快于对照组(P<0.05),观察组总创面肉芽生长状况要优于对照组(P<0.05)。观察组治疗后残余创面面积、创面愈合时间及住院时间均少于对照组(P<0.05)。愈合3个月后随访调查,两组患者烧伤创面均愈合,并遗留不同程度的瘢痕。观察组瘢痕量表各项指标评分均低于对照组(P<0.05)。结论:重组牛碱性成纤维细胞生长因子联合负压引流促进Ⅱ度烧伤患者创面愈合的治疗效果满意。
Objective： To observe the clinical effect of recombinant bovine basic fibroblast growth factor（rb FGF） combined with negative pressure drainage on wound healing in patients with second degree burn.Methods： A total of 64 patients with grade Ⅱ burn from April 2016 to April 2017 in our hospital were selected for study. According to patients with different treatment methods they were divided into observation group and control group,32 cases in each group. The control group was treated with negative pressure drainage and the observation group was treated with rb FGF and negative pressure drainage. The clinical effects of wound healing in both groups were compared. Results： The growth of superficial second-degree burns granulation in the observation group was significantly faster than that in the control group（P 0.05）. The total wound granulation growth in the observation group was better than that in the control group（P 0.05）. The residual wound area,wound healing time and hospital stay in the observation group were less than those in the control group after treatment（P 0.05）. After 3 months of healing,a follow-up survey was conducted. All the burn wounds healed in both groups,leaving scar of different degree. Scores in the observation group were lower than those in the control group（P 0. 05）. Conclusions： Recombinant bovine basic fibroblast growth factor combined with negative pressure drainage is an ideal treatment for wound healing in patients with second degree burn.
作者
向光俊
XIANG Guangjun(China Three Gorges University,Hubei Yichang 443000,Chin)
出处
《河北医学》
CAS
2018年第8期1343-1346,共4页
Hebei Medicine
基金
湖北省自然科学基金项目
(编号:2015CFB2362)
关键词
重组牛碱性成纤维细胞生长因子
负压引流
Ⅱ度烧伤
创面愈合
Recombinant bovine basic fibroblast growth factor
Negative pressure drainage
Ⅱdegree bums
Wound healing
