摘要
目的观察外用碱性成纤维细胞生长因子联合超短波治疗糖尿病足溃疡的临床疗效。方法选择我院内分泌科于2015年1月至2016年4月期间收治的72例2型糖尿病合并糖尿病足溃疡患者为研究对象,根据随机数表法分为观察组和对照组,每组36例,对照组患者予控制血糖、抗感染等常规治疗,观察组患者在此基础上加用重组牛碱性成纤维细胞生长因子及超短波治疗,7 d为一个疗程,治疗3个疗程。一个疗程后进行临床症状评分,3个疗程后比较两组患者的临床疗效。结果治疗7 d后,观察组患者的肉芽生长、渗出及水肿的症状评分分别为(0.96±0.39)分、(1.25±0.57)分及(1.42±0.66)分,均明显低于对照组的(1.38±0.58)分、(1.64±0.69)分及(1.97±0.85)分,差异均有统计学意义(P<0.05);治疗后,观察组患者的治疗总有效率为88.89%,明显高于对照组的69.44%,差异有统计学意义(P<0.05)。结论外用碱性成纤维细胞生长因子联合超短波治疗糖尿病足溃疡可以促进肉芽组织的生长、减少渗出及水肿,促进溃疡创面的愈合。
Objective To study the clinical effect of topical basic fibroblast growth factor combined with ultrashort wave in the treatment of diabetic foot ulcers. Methods A total of 72 patients with type 2 diabetes mellitus and diabetic foot ulcers, who admitted to Department of Endocrine of our hospital from January 2015 to April 2016, were selected and divided into the observation group（n=36） and the control group（n=36） according to random number method.The control group was treated with routine therapy such as blood glucose control and anti-infection, based on which, the observation group was treated with recombinant bovine basic fibroblast growth factor and ultrashort wave therapy. Taking 7 days for one course, all these patient were treated for three courses. After one course, the clinical symptoms were scored; after three courses, the clinical curative effect of the two groups was compared. Results After 7 days of treatment, the scores of granulation growth, exudation and edema of the observation group were respectively（0.96 ± 0.39）,（1.25±0.57） and（1.42±0.66）, which were significantly lower than（1.38±0.58）,（1.64±0.69） and（1.97±0.85） of the control group（P〈0.05）. After treatment, the total effective rate of the observation group was 88.89%, which was significantly higher than 69.44% of the control group（P〈0.05）. Conclusion Topical basic fibroblast growth factor combined with ultrashort wave for treatment of diabetic foot ulcers can promote granulation tissue growth, reduce exudation and edema,and promote ulcer wound healing.
出处
《海南医学》
CAS
2017年第5期734-736,共3页
Hainan Medical Journal
基金
广东省中山市科技计划项目(编号:2014A020027)
