摘要
目的比较经鼻持续气道正压通气(NCPAP)与经鼻间歇正压通气(NIPPV)在新生儿呼吸窘迫综合征(NRDS)中的呼吸支持效果。方法选择我院新生儿科2014年5月—2015年4月收治的NRDS患儿60例,随机分为NCPAP组(n=30)和NIPPV组(n=30)。比较两组治疗后的治疗成功率、吸入氧浓度(FiO_2)、血气分析结果、呼吸支持时间、氧疗时间、开奶时间、住院时间和并发症发生率。结果 NCPAP组治疗成功20例(66.67%),NIPPV组治疗成功28例(93.33%),两组比较差异有统计学意义(P<0.05)。NIPPV组治疗后1h、24h、48h的pH值、PaO_2、PaCO_2比NCPAP组改善显著,FiO_2更低,两组比较差异均有统计学意义(P<0.05)。NIPPV组呼吸支持时间、氧疗时间及住院时间均短于NCPAP组,开奶时间较NCPAP组早,两组比较差异均有统计学意义(P<0.001)。两组并发症发生率比较,NIPPV组腹胀发生率更低(P<0.05),其余(包括气胸、鼻损伤、脑室内出血、早产儿视网膜病和支气管肺发育不良)差异均无统计学意义(P>0.05)。结论对NRDS患儿行无创呼吸支持时,NIPPV的疗效比NCPAP更显著,可降低并发症的发生率。
Objective To compare the respiratory support efficacy of nasal continuous positive airway pressure（NCPAP）with nasal intermittent positive pressure ventilation（NIPPV）for neonatal respiratory distress syndrome（NRDS）. Methods Sixty children with NRDS who were treated at neonatology department of our hospital from May 2014 to April 2015 were selected and were randomly divided into NCPAP group（n=30）and NIPPV group（n =30）.After treatment,the success rate of treatment,fraction of inspired oxygen（FiO2）,blood gas analysis,respiratory support time,oxygen therapy time,start of feeding time,hospital duration and complication rates were compared between the two groups. Results Twenty cases（66.67%）of the NCPAP group had successful outcome and 28 cases（93.33%）of the NIPPV group had successful outcome,there was statistically significant difference by comparison between the two groups（P〈0.05）.Compared with NCPAP group,pH,PaO2 and PaCO2 of 1 h,24 h,48 hafter treatment of NIPPV group were significantly improved,and FiO2 was lower,and there were all statistically significant differences by comparison between the two groups（P〈0.05）.NIPPV group had shorter respiratory support time,oxygen duration and hospital duration than NCPAP group,the start of feeding time of NIPPV group was earlier than that of NCPAP group,and there were all statistically significant differences by comparison between the two groups（P〈0.001）.By comparison of complication rates between the two groups,the incidence of abdominal distension was lower in NIPPV group（P〈0.05）,and there were no statistically significant differences in other indexes（including pneumothorax,nose injuries,intraventricular hemorrhage,retinopathy of prematurity and bronchopulmonary dysplasia）（P〉0.05）. Conclusion When noninvasive breathing support is used for NRDS,NIPPV is more significantly effective than NCPAP and it can reduce complications.
作者
胡岩
黄菊枫
吴海涛
高广华
郑雪
Hu Yan;Huang Jufeng;Wu Haitao;Gao Guanghua;Zheng Xue(Department of Neonatology,Shuyang Affiliated Hospital of Nanjing University of Chinese Medicine,Shuyang 223600,Jiangsu,Chin)
出处
《右江民族医学院学报》
2018年第3期243-246,共4页
Journal of Youjiang Medical University for Nationalities
关键词
经鼻间歇正压通气
经鼻持续气道正压通气
呼吸窘迫综合征
新生儿
nasal intermittent positive pressure ventilation
nasal continuous positive airway pressure
respiratory distress syndrome
neonate
