摘要
目的探讨瑞舒伐他汀短期强化治疗对急性冠状动脉综合征(ACS)患者行经皮冠状动脉介入治疗术(PCI)后心功能及炎性反应的影响。方法选择2014年1月至2015年1月接受PCI手术的ACS患者166例,按照随机数表法患者分为对照组和研究组,每组83例。PCI术后,对照组患者行常规治疗,研究组患者在常规治疗的基础上加用瑞舒伐他汀钙片,疗程1个月。分别于治疗前后检测患者心脏功能及结构,应用全自动生化分析仪检测患者血液中肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白(c Tn I)水平,同时采用酶联免疫吸附测定法检测炎性反应相关指标,分析2组患者不良反应和心脏不良事件的发生率。结果治疗结束后,2组患者CK-MB、c Tn I、左心室射血分数(LVEF)及心室舒张早期左心房室瓣血流峰值流速/心室舒张晚期左心房室瓣血流峰值流速(E/A)值明显高于治疗前,左心室收缩末期内径(LVSD)和左心室舒张末期内径(LVDD)明显低于治疗前,研究组患者心功能指标改善情况显著优于对照组,差异均有统计学意义(P<0.05);与治疗前比较,2组患者治疗后超敏C-反应蛋白(hs-CRP)、脑尿钠肽(BNP)、肿瘤坏死因子(TNF)-α及白介素(IL)-6水平明显下降,研究组患者各炎症指标水平显著低于对照组,差异均有统计学意义(P<0.05);对照组和研究组患者不良反应发生率分别为7.22%(6/83)和6.02%(5/83),而心血管事件发生率分别为16.87%(14/83)和14.46%(12/83),但差异无统计学意义(χ2=0.097、0.182,P=0.755、0.669)。结论瑞舒伐他汀短期强化治疗可有效改善行PCI术后ACS患者的心功能和炎性反应,并且药物安全性较高,值得临床推广应用。
Objective To explore the effects of rosuvastatin short term intensive therapy on cardiac function and inflammatory response of patients with acute coronary syndrome（ ACS） after percutaneous coronary intervention（ PCI）.Methods A total of 166 patients with ACS who were treated by PCI in our hospital from January 2014 to January 2015 were divided into control group（ n = 83） and research group（ n = 83） according to random number table. After PCI,the patients in control group were treated by routine treatment,howeve,the patients in research group,on the basis of control group,were treated by oral rosuvastatin tablets,with a treatment couse of one month for both groups. The cardiac function and structure of patients were detected before and after treatment respectively,and the levels of creatine kinase isoenzyme（ CK-MB） and myocardial troponin（ c Tn I） in blood were detected by full automatic biochemical analyzer. At the same time,inflammatory response related indexes were tested by enzyme-linked immunosorbent assay. In addition,the incidence rates of adverse reactions and cardiac adverse events were statistically analyzed. Results After treatment,the levels of CK-MB,c Tn I,left ventricular ejection fraction（ LVEF）,early ventricular diastolic peak velocity/late ventricular diastolic peak velocity of blood flow to the left atrioventricular valve（ E/A） values were significantly increased in both groups. Moreover the left ventricular end systolic inner diameter（ LVSD） and left ventricular end diastolic inner diameter（ LVDD） in both groups were significantly lower than those before treatment. As compared with those before treatment,the levels of high-sensitivity Creactive protein（ hs-CRP）,brain natriuretic peptide（ BNP）,tumor necrosis factor-α（ TNF-α） and interleukin-6（ IL-6）were significantly decreased after treatment in both groups,moreover the levels of inflammatory indexes in research group were significantly lower than those in control group（ P 0. 05）. In a
作者
石清
李俊
程康
田季雨
SHI Qing;LI Jun;CHENG Kang(Department of Internal Medicine,No.518 Hospital of PLA,Shaanxi,Xi＇ an 710000,China)
出处
《河北医药》
CAS
2018年第13期1972-1975,共4页
Hebei Medical Journal
