摘要
目的探讨急性脑梗死患者接受不同剂量瑞舒伐他汀治疗后对其认知功能、炎性因子的影响。方法选择2017年5月至2019年5月我院收治的80例急性脑梗死患者为研究对象,利用随机数字表法分为对照组(n=40,接受低剂量瑞舒伐他汀治疗)与观察组(n=40,接受高剂量瑞舒伐他汀治疗)。对比治疗后两组患者认知功能、炎性因子、总治疗效果。结果治疗后,观察组治疗总有效率高于对照组(97.50%vs.80.00%),差异有统计学意义(p<0.05);观察组治疗后MMSE评分低于对照组,血清中IL-6、TNF-α、hs-CRP水平低于对照组,差异有统计学意义(p<0.05)。结论急性脑梗死患者给予高剂量的瑞舒伐他汀治疗,能够显著提高治疗效果,改善其认知功能,有效抵抗炎性反应。
Objective To investigate the effect of different doses of rosuvastatin on cognitive function and inflammatory factors in patients with acute cerebral infarction.Methods 80 patients with acute cerebral infarction in the hospital from May 2017 to May 2019 were selected as subjects.They were divided into control group(n=40,low dose of rosuvastatin)and observation group(n=40,high dose of rosuvastatin)according to random number table.The cognitive function,inflammatory factors,total curative effects were compared between two groups after treatment.Results After treatment,the total effective rate of observation group was higher than that of control group(97.50%vs.80.00%)(p<0.05);After treatment,the score of MMSE in observation group was lower than that in control group,the levels of serum IL-6,TNF-αand hs-CRP in observation group were lower than those in control group(p<0.05).Conclusions High dose of rosuvastatin in treatment of patients with acute cerebral infarction can increase curative effects,improve cognitive function,and resist inflammatory response.
作者
曹修建
Cao xiujian(Taiqian County People's Hospital,Puyang Henan,457600,China)
出处
《临床心电学杂志》
2019年第5期358-361,共4页
Journal of Clinical Electrocardiology
关键词
急性脑梗死
瑞舒伐他汀
不同剂量
认知功能
炎性因子
acute cerebral infarction
rosuvastatin
different doses
cognitive function
inflammatory factors
