摘要
目的探讨肝动脉灌注化疗栓塞术(transarterial chemoembolization,TACE)治疗原发性肝癌后肝功能损伤发生状况和影响因素。方法回顾性分析120例经TACE治疗的原发性肝癌患者肝功能出现损伤的发生情况与病例的性别、年龄、肿瘤体积、手术前肝功能分级、TACE操作次数、选择肿瘤栓塞供血动脉和肝硬化分级的关系。结果原发性肝癌患者在经过TACE治疗后,是否发生肝功能损伤与患者的性别、年龄、肿瘤体积和Child-Pugh分级关系之间的数据未见相关性(P>0.05);出现肝功能损伤病例中:行TACE次数>2次有15例(15/46),≤2次仅6例(6/74),两者比较,χ~2=11.794,P=0.001;肝硬化分级Ⅰ级、Ⅱ级、Ⅲ级及以上者分别是1(1/36)、6(6/40)、14(14/44)例,三者比较,χ~2=11.826,P=0.003;进一步分析,肝功能损伤与行TACE次数呈正相关(r_s=0.403,P<0.05);肝功能损伤与肝硬化分级呈正相关(r_s=0.327,P<0.05)。结论原发性肝癌在经过TACE治疗后,患者是否发生肝功能损伤与行TACE次数、患者肝硬化分级两个因素呈显著性相关,所以在治疗过程中,应该严格掌握患者本身的肝硬化情况,尽量减少TACE操作次数,减少肝功能损伤。
Objective To investigate the status and influencing factors of hepatic function injury after transcatheter hepatic arterial chemoembolization（ TACE） treatment of primary liver cancer. Methods 120 cases of primary liver cancer were treated by TACE method. The relationship between the occurrence of liver function injury in these cases and the sex,age,tumor volume,preoperative liver function classification,TACE operation times,selection of arterial blood supply artery and grade of liver cirrhosis in these cases were analyzed retrospectively. Results There was no correlation between the liver function injury and the sex,age,tumor volume,and Child-Pugh classification of patients with primary liver cancer after TACE treatment（ P〈0. 05）. In the cases of liver fanction injury：15 cases（ 15/46） were treated with TACE more than 2 times,and just 6 cases（ 6/74） were treated with TACE no more than 2 times.The results of comparison between the two groups were as follows： χ^2= 11. 794,P = 0. 001; liver cirrhosis grade1,grade2,grade3 and above were respectively： 1（ 1/36） 、6（ 6/40） 、14（ 14/44）,among the three groups,the results were as follows： χ^2= 11. 826,P = 0. 003.The liver function injury was related to the number of TACE times rs= 0. 403,P〈0. 05,and the liver function injury and the classification of liver cirrhosis rs= 0. 327,P〈0. 05. Conclusions After treatment with TACE,whether the liver function damage is significantly related to the two factors of TACE and the grade of liver cirrhosis. Therefore,in the treatment process,we should strictly grasp the patient＇s condition of cirrhosis,minimize the number of TACE operations,and reduce the damage of liver function.
作者
罗红兰
刘凯
朱晓东
姬生威
刘静
LUO Hongan;LIU Kai;ZHU Xiaodong;JI Shengwei;LIU Jing(Oncology Department,Huanggang Central Hospital,Huanggang,Hubei 438000,China)
出处
《安徽医药》
CAS
2018年第7期1366-1368,共3页
Anhui Medical and Pharmaceutical Journal
关键词
肝肿瘤
化学栓塞
治疗性/副作用
肝功能试验
肝动脉
肝硬化
Liver neoplasms
Chemoembolization
therapeutic/adverse effects
Liver function tests
Hepatic artery
Liver cirrhosis
