摘要
目的探讨高频重复经颅磁刺激治疗对精神分裂症慢性病程患者的阴性症状改善作用的持续性。方法选择2015年9月~2016年9月在北京市大兴区精神病医院住院的以阴性症状为主的慢性精神分裂症患者40例,使用高频重复经颅磁刺激进行治疗,收集治疗前,治疗结束,治疗结束后1、3、6个月的相关数据,采用阳性和阴性症状量表(PANSS)、副反应量表(TESS)评价疗效及不良反应。结果患者治疗前,治疗结束,治疗结束后1、3、6个月的PANSS量表中的阴性症状评分与总评分数据差异均有统计学意义(F=45.621,57.369,P<0.05),q检验结果显示,治疗结束与治疗结束后1个月的数值均低于治疗前,治疗结束后3个月,治疗结束后6个月,差异均有统计学意义(P<0.05)。治疗前统计有2例"震颤"患者和1例"流涎"患者,在治疗结束后症状无明显变化,在不同治疗时间点的TESS量表中严重程度评分数据差异无统计学意义(F=1.254,P<0.05)。结论高频重复经颅磁刺激治疗精神分裂症可以在短期内改善其临床症状,特别是阴性症状的改善幅度较大,但是改善的效果会因时间的延长而逐渐减弱,建议进行连续治疗。
Objective To investigate the sustainability of high frequency repetitive transcranial magnetic stimulation on sustainability of the improvement role for negative symptoms in schizophrenic patients with chronic course of disease.Methods From September 2015 to September 2016,40 patients with negative symptoms of chronic schizophrenia hospitalized in Mental Hospital of Daxing District in Beijing City were selected.High frequency repetitive transcranial magnetic stimulation was used for treatment.Data were collected before treatment,end of treatment,1,3 months and 6 months after treatment.Positive and negative symptom scale（PANSS） and side effects scale（TESS） were used to evaluate efficacy and side effects.Results The difference between the negative symptom scores and the total score data in the PANSS scale before treatment,at the end of treatment,1,3 months and 6 months after treatment were statistically significant（F=45.621,57.369,P〈0.05）.The results of q test showed that the values at the end of treatment and 1 months after treatment were all lower than those before treatment,after the end of treatment 3,6 months,the differences were statistically significant（P〈0.05）.Before treatment,there were 2 cases of ＂tremor＂ patients and 1 case of ＂cast＂ patients,there was no significant change in symptoms after treatment.There was no statistical significance in the difference of severity score data in the TESS scale of different time points（F=1.254,P〈0.05）.Conclusion High frequency repetitive transcranial magnetic stimulation treating schizophrenia can improve their clinical symptoms in the short term.In particular,the negative symptoms have been improved greatly,but the effect of the improvement will be gradually weakened due to the prolongation of the time,continuous treatment is recommended.
作者
蔡广超
关勇
齐明
李朝晖
王江
CAI Guang-Chao;GUAN Yong;QI Ming;LI Zhao-Hui;WANG Jiang(Agricultural Treatment and Rehabilitation Center of Mental Sickness in Daxing District of Beijing City,Beijing102602,China;The Fifth Ward of Department of Geriatrics,Mental Hospital of Daxing District in Beijing City,Beijing102600,China;Outpatient Department,Mental Hospital of Daxing District in Beijing City,Beijing 102600,China)
出处
《中国当代医药》
2018年第16期12-15,共4页
China Modern Medicine
基金
北京市大兴区科技发展计划项目(KT2016000053)
关键词
重复经颅磁刺激
精神分裂症
阴性症状
随访
Repetitive transcranial magnetic stimula-tion
Schizophrenia
Negative symptoms
Follow-up
