摘要
背景:近年来,我国高脂血症性急性胰腺炎(HLAP)发病率逐年上升。研究显示约三分之一的HLAP患者有糖尿病史,然而关于糖尿病对HLAP的影响,目前仍缺乏足够的认识。目的:比较2型糖尿病合并HLAP与无糖尿病HLAP患者临床特点的差异,探讨2型糖尿病对HLAP病情的影响。方法:回顾性连续纳入徐州医科大学附属医院2014年8月—2017年8月收治的HLAP病例82例,分为糖尿病组和非糖尿病组,比较两组血清三酰甘油水平和胰腺炎严重程度的差异。采用多因素Logistic回归分析HLAP重症化的危险因素。结果:82例HLAP患者中28例(34.1%)本次发病前已确诊2型糖尿病。糖尿病组血清三酰甘油水平、肥胖者比例、APACHEⅡ评分、CTSI评分、重度急性胰腺炎比例明显高于非糖尿病组,差异有统计学意义(P<0.05)。多因素分析显示糖尿病史是HLAP重症化的独立危险因素(OR=4.385,95%CI:1.060～18.134,P=0.041)。结论:2型糖尿病是HLAP的危险因素之一,且在一定程度上可加重HLAP病情。
Background： The incidence of hyperlipidemic acute pancreatitis（ HLAP） increased significantly in China over the past decades. It has been reported that a history of diabetes mellitus（ DM） was present in approximate one third of the HLAP patients,however,the influence of DM on HLAP is not fully understood. Aims： To explore the influence of type 2 DM on HLAP through comparing the clinical features between HLAP patients with and without type 2 DM. Methods： The medical records of 82 consecutive cases of HLAP admitted to the Affiliated Hospital of Xuzhou Medical University from Aug. 2014 to Aug. 2017 were reviewed. These patients were divided into DM group and non-DM group and their serum level of triglyceride and the severity of pancreatitis were compared. Multivariate Logistic regression analysis was used to identify the risk factors for severe acute pancreatitis. Results： Of the 82 HLAP patients,28（ 34. 1%） were diagnosed as having type 2 DM prior to the episode of pancreatitis. The serum level of triglyceride,APACHE Ⅱ score,and CTSI score were significantly higher,and obesity and severe acute pancreatitis were more frequent in DM group than in non-DM group（ P 〈 0. 05）. Multivariate analysis revealed that history of DM was associated independently with severe acute pancreatitis（ OR = 4. 385,95% CI： 1. 060-18. 134,P = 0. 041）. Conclusions： Type 2 DM is a risk factor for HLAP and may aggravate the severity of the disease.
作者
黄瑶
王营
HUANG Yao;WANG Ying(Xuzhou Medical University,Xuzhou,Jiangsu Province 221004;Department of Gastroenterology,the Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu Province)
出处
《胃肠病学》
2018年第7期423-425,共3页
Chinese Journal of Gastroenterology
关键词
糖尿病
2型
高脂血症
三酰甘油
胰腺炎
Diabetes Mellitus
Type 2
Hyperlipidemias
Triglyeeride
Panereatitis
