摘要
目的探讨复方苦参注射液联合化疗对肺癌患者疗效及免疫功能、生活质量的影响。方法非小细胞肺癌（NSCLC）患者80例随机分为对照组与观察组，每组各40例。对照组患者给予PP方案化疗，观察组患者在pp方案化疗的基础上联合复方苦参注射液治疗。分别检测并比较两组患者疗效、毒副反应及治疗前后两组免疫功能、生活质量变化。结果对照组患者治疗总有效率27．5％，观察组治疗总有效率52．5％，两组比较差异有统计学意义（P〈0．05）。观察组胃肠道反应、肝功能损害、肾功能损害、粒细胞减少、脱发方面毒副反应发生率比对照组低，尤其是在胃肠道反应、粒细胞减少发生率显著低于对照组，差异有统计学意义（P〈0．05）。观察组治疗后CD3^＋、CD4^＋、CD4^＋／CD8^＋含量显著高于对照组，差异有统计学意义（P〈0．05）；两组CD8^＋含量变化不明显，差异无统计学意义（P〉0．05）。治疗后观察组整体生活质量、躯体功能、角色功能、认知功能评分方面显著高于对照组，差异有统计学意义（P〈0．05）。结论复方苦参注射液联合化疗治疗NSCLC疗效显著，有助于降低化疗引起的毒副反应、增强机体免疫力、提高患者生活质量。可以作为肺癌化疗过程中的辅助药物，值得临床推广。
Objective To investigate effects of compound Kushen injection combined with chemotherapy on efficacy, immune function and quality of life of patients with lung cancer. Methods Eighty non-small cell lung cancer （ NSCLC ） patients were randomly divided into control group and observation group, 40 cases in each group. The patients in the control group were given PP regimen and the patients in the observation group were treated with compound Kushen injection on the basis of PP regimen. The curative effects, side effects and the immune function and quality of life of the two groups before and after treatment were detected and compared respectively. Results After treatment, the total effective rate （ CR＋PR ） was 27.5% in the control group and 52.5% in the observation group.The total effective rate of the two groups was significantly different （ P〈0.05 ） .After treatment, the incidences of side effects of gastrointestinal tract, liver function, renal dysfunction, neutropenia and hair loss in the observation group were lower than those in the control group, especially the incidences of gastrointestinal reaction and neutropenia were significantly lower than the control group, the difference were significant in statistical （ P〈0.05 ） .The levels of CD3^＋, CD4^＋, CD4^＋/CD8^＋ in the two groups were significantly higher than those in the control group after treatment （P〈0.05） , but the level of CD8^＋ was no significant difference between the two groups. After treatment, the observation group was significantly higher than the control group in terms of overall quality of life, body function, role and cognitive function score, the difference was statistically significant （P〈0.05） . Conclusion Compound Kushen injection combined with chemotherapy for the treatment of NSCLC is significant effect, and can help to reduce chemotherapy-induced side effects, enhance immunity, improve patient quality of life, so it can be used as chemotherapy drags in lung cancer, which is worthy of clinical pr
出处
《浙江临床医学》
2018年第7期1161-1163,共3页
Zhejiang Clinical Medical Journal
基金
国家自然科学基金（81703018）
关键词
复方苦参注射液
化疗
非小细胞肺癌
免疫功能
生活质量
Compound Kushen injection Chemotherapy Non-small cell lung cancer Immune function Quality of life
