摘要
目的:评价复方苦参注射液对晚期非小细胞肺癌化疗的作用。方法:治疗组45例采用复方苦参注射液联合化疗,对照组43例行单纯化疗,化疗方案相同。2～6个周期后判定疗效。结果:①治疗组有效率(CR+PR+SD)为73.3%,对照组有效率为69.8%,但无统计学意义(P>0.05)。②各主要系统的毒副反应治疗组较对照组减轻(P<0.05)。③化疗后生存质量改善方面,治疗组优于对照组(P<0.05)。结论:复方苦参注射液联合化疗虽不能提高临床疗效,但可以减轻化疗不良反应,提高患者生存质量。
Objective： To evaluate the effects of compound Kushen injection in combination with chemotherapy for patients with stage-Ⅲ~Ⅳ non-small cell lung cancer.Methods： A total of 88 patients with stage-Ⅲ~Ⅳ non-small cell lung cancer were enrolled,among which 45 were assigned to the trial group to receive compound Kushen injection in combination with chemotherapy and 43 were assigned to the control group to receive chemotherapy alone.The efficacies of the two regimens were evaluated 2~6 weeks later.Results： The total responsive rates（tumor stabilization rates） in the trial group and the control group were 73.3% and 69.8%,respectively.There was no significant difference between the two groups in response rate（P0.05）.The major toxic reactions had a better alleviation in the trial group than in the control group（P0.05）.The life quality had a better improvement in the trial group than in control group after the therapy（t=11.6,P0.05）.Conclusion： Although compound Kushen injection combined with chemotherapy can not improve the total responsive rate,it can alleviate the symptoms,reduce the toxicity of chemotherapy,and improve the quality of life.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2012年第5期537-539,共3页
Chinese Journal of New Drugs
关键词
复方苦参注射液
非小细胞肺癌
减毒作用
compound Kushen injection
non-small cell lung cancer
reduce the toxic reactions
