摘要
目的:采用Meta分析评估基质金属蛋白酶-9(MMP-9)基因多态性对胃癌遗传易感性的影响。方法:通过PubMed、Embase、CNKI和万方数据库(至2017年5月17日)检索相关研究。采用Stata 12.0进行统计学分析,计算合并比值比(odds ratio,OR)及95%可信区间(confidence interval,CI),使用Q检验和I2值评估研究之间的异质性,并进行亚组分析、敏感性分析和发表偏倚检测。结果:最后纳入7项研究,纯合子模型TT vs.CC(OR=1.70,95%CI=1.06~2.72,P=0.027),隐性模型TT vs.CC+CT(OR=1.74,95%CI=1.22~2.71,P=0.01)两种基因模型下均观察到显著相关性,差异有统计学意义;T vs.C,CT vs.CC,CT+TT vs.CC三种基因模型与胃癌无显著相关性,差异无统计学意义。亚组分析和敏感性分析显示结果真实可靠。结论:该Meta分析表明,MMP-9-1562 C>T多态性与胃癌易感性明显相关,TT基因型携带者的胃癌易感性高于CC人群和CC+CT人群。受纳入研究数量和质量限制,尚需开展大样本、高质量的随机对照试验进一步论证上述结论。
Objective Meta-analysis was performed to evaluate the effect of MMP-9 gene polymorphism on the genetic susceptibility of gastric cancer. Methods Related researches were recognized by searching PubMed,Embase,CNKI and Wanfang databases（ until May 17,2017）. Odds ratio（ OR） and 95% confidence interval（ CI） were calculated and analyzed using Stata 12.0 software,and heterogeneity between studies were assessed using the Q test and I^2 value. The Begg＇s funnel plot and Egger＇s test were performed to evaluate the publication bias of literatures. Results Finally seven relative reports on MMP-9-1562 CT（ rs3918242） were included. For MMP-9-1562 CT,significant association was observed under two genetic models in the overall（ TT vs.CC; TT vs.CC＋CT）,however,the non-significantly increased risk was shown in T vs.C,CT vs.CC,CT＋TT vs.CC. Subgroup analysis and sensitivity analysis showed that the results were reliable. Publication bias was not detected by either funnel plot or Egger＇s tests. Conclusion This meta-analysis suggested that MMP-9-1562 CT polymorphism was significantly associated with increased risk of gastric cancer. Patients with TT genotype had higher gastric cancer susceptibility than those with CC and CC ＋ CT. Owing to the quantity and quality limitations of the included studies,a large sample and high quality randomized controlled trial are needed to further demonstrate the above conclusions.
作者
张焕鑫
袁平
赵继先
李波
王家宁
唐俊明
沈俊
ZHANG Huan-xin;YUAN Ping;ZAHO Ji-xian;LI Bo;WANG Jia-ning;TANG Jun-ming;SHEN Jun(Department of Cardiology;Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China)
出处
《湖北医药学院学报》
CAS
2017年第6期491-495,500,共6页
Journal of Hubei University of Medicine
基金
国家自然科学基金(81270221,81170095)
湖北省自然科学基金(2014CFB644)
