摘要
目的:探讨克龄蒙联合戈舍瑞林对子宫内膜异位症患者腹腔镜术后血清激素水平的影响。方法:将81例子宫内膜异位症患者分为研究组和对照组。全部患者采用腹腔镜手术治疗。对照组术后给予戈舍瑞林治疗。研究组在对照组基础上,给予克龄蒙治疗。检测两组治疗前后雌二醇(E2)、卵泡刺激素(FSH)、促黄体生成素(LH)、血清癌抗原125(CA125)的水平。记录两组的不良反应发生情况。治疗结束后随访6个月,记录两组患者的妊娠及复发情况。结果:两组的总有效率对比,差异无统计学意义(P>0.05);两组治疗后的E2、FSH、LH、CA125较治疗前均明显降低(P<0.05);治疗后,研究组的E2、LH明显高于对照组,FSH明显低于对照组,差异有统计学意义(P<0.05);两组治疗后CA125对比,差异无统计学意义(P>0.05);研究组的不良反应发生率(9.76%)明显低于对照组(27.50%),差异有统计学意义(P<0.05);研究组的复发率、妊娠率与对照组对比,差异无统计学意义(P>0.05)。结论:克龄蒙联合戈舍瑞林能显著改善子宫内膜异位症患者腹腔镜术后E2、LH水平,降低不良反应的发生。
AIM： To investigate the effects of climen associated with goserelin on serum hormone levels of laparoscopic surgery in patients with ectopic endometrium after laparoscopic hysterectomy.METHODS： Eighty-one patients with endometriosis were divided into study group and control group. All patients were treated with laparoscopic surgery. The control group was given goserelin treatment after operation. The research group was given climen treatment based on the control group. The levels of E2,FSH,LH and CA125 were detected before and after treatment in the two groups. Adverse reactions were recorded in the two groups. The patients were followed up for 6 months after the treatment,and the pregnancy and recurrence of the two groups were recorded. RESULTS： The total effective rates of the two groups were compared. The difference was not statistically significant（ P〈0. 05）. After treatment,E2,FSH,LH,CA125 in two groups were significantly lower than those before treatment（ P〉0. 05）. After treatment,the levels of E2 and LH in the study group were significantly higher than those in the control group,and FSH was significantly lower than that in the control group. The difference was statistically significant（ P〈0. 05）. Comparison of CA125 in two groups after treatment,the difference was not statistically significant（ P〉0. 05）. The incidence of adverse reactions in the study group（ 9. 76%） was significantly lower than that in the control group（ 27. 50%）. The difference was statistically significant（ P〈0. 05）. The recurrence rate and pregnancy rate of the study group were compared with those of the control group. The difference was not statistically significant（ P〉0. 05）. CONCLUSION： Climen associated with goserelin can significantly improve the levels of E2,LH in patients with endometriosis after laparoscopic surgery and reduce the occurrence of adverse reaction.
作者
桂华
曹珊珊
赵巧云
王佩红
GUI Hua;CAO Shanshan;ZHAO Qiaoyun;WANG Peihong(Taizhou City of Integrated Traditional Chinese and Western Medicine, Obstetrics and Gynecology, Taizhou 317523, Zhejiang, China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2018年第5期557-560,共4页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
浙江省自然科学基金(LQ16H040001)
