摘要
【目的】 探讨腹腔镜手术辅助醋酸曲普瑞林治疗子宫内膜异位症合并不孕症的临床疗效。【方法】 选择本院诊治的子宫内膜异位症合并不孕症患者72例,按照随机数表法分为对照组和观察组,每组36例。所有患者均进行腹腔镜手术治疗,对照组给予孕三烯酮治疗,观察组给予醋酸曲普瑞林辅助治疗,两组均持续治疗6个月。比较两组治疗前后痛经评分、子宫内膜异位症生存质量量表(EHP-5)评分及血清激素[促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)]水平,评价两组临床疗效,观察两组妊娠结局及不良反应。【结果】 治疗后,两组痛经评分、EHP-5评分及血清LH、FSH、E2水平均显著降低(P<0.05),且观察组显著低于对照组(P<0.05)。观察组总有效率显著高于对照组,妊娠结局显著优于对照组,肝功能损伤发生率显著低于对照组,其差异均有统计学意义(P<0.05)。【结论】 腹腔镜手术辅助醋酸曲普瑞林治疗宫内膜异位症合并不孕症疗效显著,可调节患者血清LH、FSH、E2水平,改善妊娠结局,值得临床推广应用。
【Objective】 To investigate the effect of laparoscopic surgery-assisted triptorelin acetate for the treatment of endometriosis with infertility.【Methods】 Seventy-two cases of endometriosis combined with infertility in our hospital were selected as the research objects. They were divided into the control group and the study group with thirty-six cases in each group according to the random number table method. All patients underwent laparoscopic surgery. The control group was given gestrinone treatment while the study group was given triptorelin acetate as adjunctive therapy. Both groups were treated for six months. We recorded the pelvic tumor size, dysmenorrhea score, endometriosis treatment life scale (EHP-5) score and serum hormone levels [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)] in the two groups before and after treatment. The clinical efficacy, pregnancy outcomes and incidence of adverse reactions of the two groups were evaluated. 【Results】 After treatment, dysmenorrhea scores, EHP-5 scores and serum LH, FSH, E2 levels in the two groups were significantly decreased (P<0.05), and those in the study group were significantly lower than in the control group (P<0.05). The total effective rate of the study group was significantly higher than that of the control group (P<0.05). The pregnancy outcome was significantly better than that of the control group (P<0.05). The incidence of liver function damage was significantly lower than that of the control group (P<0.05). 【Conclusion】 The therapeutic effect of laparoscopic surgery-assisted triptorelin acetate in the treatment of endometriosis associated with infertility is significant. It can regulate the serum levels of LH, FSH and E2 and improve the outcome of pregnancy.
作者
米桂兰
舒志明
吴建发
柳洲
MI Gui-lan;SHU Zhi-ming;WU Jian-fa(Department of Obstetrics and Gynecology,Zhoupu Hospital Affiliated to Shanghai University of Medicine and Health Sciences,Shanghai 201318 China)
出处
《医学临床研究》
CAS
2019年第1期32-34,37,共4页
Journal of Clinical Research
基金
上海市浦东新区卫生系统重点学科建设项目(编号:PWZxk2017-14).
