摘要
人类免疫缺陷病毒(HIV)感染CD4+T细胞,造成免疫系统功能紊乱,导致适应性免疫和固有免疫均发生异常。肠道是人体重要的CD4+T细胞库,因此,肠道也是病毒感染的主要目标,此外,人肠道内居住着数以亿计的微生物,近年来发现这些微生物群在人类健康中起关键作用。HIV感染除了直接改变肠道CD4+T细胞组成,也改变了肠道微生物的组成和功能。本文综述了HIV引起的肠道微生物改变,并探讨这些改变在HIV感染个体中产生的局部及系统效应与相关的系统病理损伤,以及用肠道微生物进行靶向调节HIV感染和相关治疗的研究进展。
The human immunodeficiency virus(HIV)attacks cluster of differentiation(CD)4+T cells,leading to dysregulation of adaptive and innate immunes.One of the main targets for viral infection is the intestinal tract,which is a reservoir of CD4+T cells.Meanwhile,the human intestinal tract harbors trillions of commensal microorganisms("the microbiota"),which have recently been shown to have pivotal roles in health.Besides the direct role of HIV infection in altering the intestinal compartment of CD4+T cells,HIV infection can change the composition and function of gut microbiota.Here,we review these alterations and discuss their potential local and systemic effects on individuals infected with HIV.We also discuss the potential roles of novel microbiota-targeting treatments in regulating HIV progression and the associated adverse systemic manifestations.
作者
余邹邹
李云
宋银宏
YU Zouzou;LI Yun;SONG Yinhong(Infection and inflammation Institute, Medical College, China Three Gorges University, Yichang 443002, China;Department of Cardiology, People's Hospital of Yichang , Three Gorges University, Yichang 443000, China)
出处
《病毒学报》
CAS
CSCD
北大核心
2018年第4期586-593,共8页
Chinese Journal of Virology
基金
国家自然科学基金(项目号:81671397),题目:含穿膜肽重组转录因子FOXN1-TAT对衰老小鼠胸腺重建的作用及其细胞和分子机制的研究~~