摘要
目的:探讨黄芪注射液对急性胰腺炎肠道屏障功能和微炎性反应状态的影响。方法:选取2016年5月至2017年5月邢台市第三医院收治的急性胰腺炎患者94例,按照随机表法分为观察组与对照组,每组47例。对照组采用常规西医治疗,观察组在对照组基础上结合黄芪注射液治疗。2组疗程均为10 d。比较2组治疗疗效、胃肠功能改善情况,及治疗前后肠道屏障功能和炎性因子水平变化。结果:观察组治疗总有效率(93.62%)高于对照组(72.34%)(P<0.05)。观察组肠鸣音恢复时间、腹胀消失时间、腹痛消失时间快于对照组(P<0.05)。与治疗前比较,2组治疗后二胺氧化酶(DAO)、D-乳酸和内毒素水平降低(P<0.05);观察组治疗后DAO、D-乳酸和内毒素水平低于对照组(P<0.05)。2组治疗后白介素-6、超敏C反应蛋白和肿瘤坏死因子-α水平降低(P<0.05);观察组治疗后白介素-6、超敏C反应蛋白和肿瘤坏死因子-α水平低于对照组(P<0.05)。结论:黄芪注射液对急性胰腺炎患者疗效明显,可改善患者肠道屏障功能和微炎性反应状态。
Objective： To investigate the effects of Huangqi Injection on intestinal barrier function and micro inflammatory state in acute pancreatitis. Methods： A total of 94 patients with acute pancreatitis admitted to our hospital from May 2016 to May 2017 were randomly divided into the observation group（ 47 cases） and the control group（ 47 cases）. The control group was treated with conventional western medicine,and the observation group was treated with Huangqi Injection on the basis of the control group. The two groups were treated for 10 d. The therapeutic effects,the improvement of gastrointestinal function and the changes of intestinal barrier function and inflammatory factors before and after treatment were compared between the two groups. Results： The total effective rate of the observation group（ 93. 62%） was higher than that of the control group（ 72. 34%）（ P 〈 0. 05）. The recovery time of bowel sound,the disappearing time of abdominal distention,abdominal pain disappeared faster than that of control group（ P 0. 05）. DAO,D-lactic acid and endotoxin levels decreased in two groups after treatment（ observation group： t = 13. 8381,23. 3904,21. 2287,the control group： t = 6. 1162,10. 2345,10. 6497,P 〈 0. 05）; DAO,D-lactic acid and endotoxin levels after treatment in the observation group were lower than the control group（ t = 9. 4356,14. 5599,13. 4744,P 〈 0. 05）. Interleukin-6 and high sensitive C reactive protein level and tumor necrosis factor alpha decreased of two groups after treatment（ observation group： t = 11. 2854,28. 4604,20. 4710,the control group： t = 4. 9671,11. 3182,7. 1438,P 〈 0. 05）; interleukin-6 and high sensitive C reactive protein and tumor necrosis factor alpha level in the observation group after treatment were lower than the control group（ t = 7. 6929,17. 3327,14. 8149,P 〈 0. 055）. Conclusion： Astragalus injection is effective in the treatment of acute pancreatitis,and can improve the intestinal barrier function and micro inflamma
作者
王嫄嫄
郑洋
周哲
董华兴
Wang Yuanyuan;Zheng Yang;Zhou Zhe;Dong Huaxing(Department of Gastroenterology, the Third Hospital of Hebei, Xingtai 054000, Chin)
出处
《世界中医药》
CAS
2018年第4期818-821,共4页
World Chinese Medicine
基金
邢台市科技计划项目(2016Z2C74)
关键词
黄芪注射液
急性胰腺炎
疗效
二胺氧化酶
D-乳酸
内毒素
白介素-6
超敏C反应蛋白
肿瘤坏死因子-α
word Astragalus injection
Acute pancreatitis
Curative effect
Diamineoxidase
D-lactic acid
Endotoxin
Interleukins-6
Hypersensitivity C reactive protein
Tumor necrosis factor-α
