摘要
目的探讨肝宁片联合异甘草酸镁注射液治疗慢性病毒性肝炎的临床疗效。方法选取2016年5月—2017年5月在南阳市第二人民医院进行治疗的慢性病毒性肝炎患者88例为研究对象,根据用药的不同将患者分为对照组和治疗组,每组各44例。对照组静脉滴注异甘草酸镁注射液,150 mg加入到5%葡萄糖注射液250 m L中,1次/d。治疗组在对照组基础上口服肝宁片,0.9 g/次,3次/d。两组患者均治疗4周。观察两组的临床疗效,比较两组的肝纤维化指标、肝功能指标和血清学指标。结果治疗后,对照组和治疗组的总有效率分别为81.82%、95.45%,两组比较差异有统计学意义(P<0.05)。治疗后,两组血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组肝纤维化指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清ALT、AST、TBIL水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组肝功能指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清转化生长因子-β_1(TGF-β_1)、巨噬细胞移动抑制因子(MIF)、白细胞介素-18(IL-18)、基质金属蛋白酶-13(MMP-13)水平均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组血清学指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论肝宁片联合异甘草酸镁注射液治疗慢性病毒性肝炎具有较好的临床疗效,可改善患者肝功能和肝纤维化指标,调节血清TGF-β_1、MIF、IL-18和MMP-13水平,具有一定的临床推广应用价值。
Objective To investigate the clinical efficacy of Ganning Tablets combined with Magnesium Isoglycyrrhizinate Injection in treatment of chronic viral hepatitis.Methods Patients（88 cases）with chronic viral hepatitis in Nangyang Second General Hospital from May 2016 to May 2017 were enrolled in this study.According to the difference treatment plan,patients were randomly divided into control and treatment groups,and each group had 44 cases.Patients in the control group were iv administered with Magnesium Isoglycyrrhizinate Injection,150 mg added into 5%glucose solution 250 m L,once daily.Patients in the treatment group were po administered with Ganning Tablets on the basis of the control group,0.9 g/time,three times daily.Patients in two groups were treated for 4 weeks.After treatment,the clinical efficacies were evaluated,and liver fibrosis indexes,liver function indexes,serological indexes in two groups were compared.Results After treatment,the clinical efficacies in the control and treatment groups were81.82%and 95.45%,respectively,and there was difference between two groups（P〈0.05）.After treatment,HA,LN,PCⅢ,andⅣ-C levels in two groups were significantly decreased,and the difference was statistically significant in the same group（P〈0.05）.And liver fibrosis indexes in the treatment group were significantly lower than those in the control group,with significant difference between two groups（P〈0.05）.After treatment,ALT,AST,and TBIL levels in two groups were significantly decreased,and the difference was statistically significant in the same group（P〈0.05）.And liver function indexes in the treatment group were significantly lower than those in the control group,with significant difference between two groups（P〈0.05）.After treatment,TGF-β_1,MIF,IL-18,and MMP-13 levels in two groups were significantly decreased,and the difference was statistically significant in the same group（P〈0.05）.And serological indexes in the treatment group were significantly lower than those in the cont
作者
王学祥
刘新群
王正茂
WANG Xue-xiang;LIU Xin-qun;WANG Zheng-mao(Department of Gastroenterology, Nangyang Second General Hospital, Nangyang 473000, Chin)
出处
《现代药物与临床》
CAS
2018年第5期1097-1100,共4页
Drugs & Clinic
关键词
肝宁片
异甘草酸镁注射液
慢性病毒性肝炎
肝纤维化指标
肝功能
血清学指标
Ganning Tablets
Magnesium Isoglycyrrhizinate Injection
chronic viral hepatitis
liver fibrosis index
liver function
serological index
