摘要
目前,中医药研究普遍存在整体与局部、宏观与微观、体内过程与活性评价脱节,建立能反映中医药整体特色的研究新策略和新方法,成为中医药现代化的当务之急。整合药理学的提出,为解决中医药研究＂碎片化＂问题提供了一条切实可行的途径。该研究基于整合药理学平台探讨斑蝥治疗结直肠癌的分子机制,借助整合药理学平台V1.0版本软件的分析功能,构建斑蝥治疗结直肠癌疾病＂核心成分-关键靶标-主要通路＂多维网络,从多个角度探索斑蝥治疗结直肠癌潜在的分子机制。通过整合药理学平台分析斑蝥治疗结直肠癌的分子机制研究中发现,斑蝥对结直肠癌的干预作用可能与氨基酸代谢、NF-κB信号通路、免疫系统、内分泌系统、神经系统以及趋化因子信号转导通路、幽门螺杆菌感染中的上皮细胞信号转导、T细胞受体信号通路、B细胞受体信号通路等有关。
At present,the disjointing situation is generally present between ＂ systemic＂ and ＂ local＂, ＂ macro＂ and ＂ micro＂, ＂ in vivo process＂ and ＂ activity evaluation＂ in the study of traditional Chinese medicine（ TCM）. An urgent task for the modernization of TCM is to establish new strategies and methods which can reflect the overall characteristics of TCM. The introduction of integrative pharmacology provided a feasible approach to solve the problem of the fragmentation of TCM. Internet-based computation platform method was adopted in this study to explore the active molecular mechanism of Mylabris in the treatment of colorectal cancer. Based on the analysis of the functional integration of internet-based computation platform V1. 0 version software,the ＂ core components-key targetmain pathway＂ multidimensional network of Mylabris in treatment of colorectal cancer disease was constructed to explore the potential molecular mechanism of Mylabris in treatment of colorectal cancer from multiple perspectives. The results showed that Mylabris can treat the colorectal cancer and the mechanism might be associated with amino acid metabolism,NF-κB signaling pathway,immune system,endocrine system,nervous system,and chemokine signal transduction pathway,epithelial cell signaling in helicobacter pylori infection,T cell receptor signaling pathway,B cell receptor signaling pathway and so on.
作者
杨磊
刘梦娇
张志国
陈文明
张琴
欧阳琳
吴萍
YANG Lei;LIU Meng-jiao;ZHANG Zhi-guo;CHEN Wen-ming;ZHANG Qin;OUYANG Lin;WU Ping(The First Hospital of Hunan University of Chinese Medicine, Zhang Zhiguo Heritage Studio Related to the Old Chinese Medicine Experts, Changsha 410007, China;Hunan University of Chinese Medicine, Changsha 410208, China;The First People＇s Hospital of Changde, Changde 415700, China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第7期1317-1322,共6页
China Journal of Chinese Materia Medica
基金
湖南省自然科学基金项目(2017JJ3247)
湖南省发改委基金项目([2016]518)
关键词
斑蝥
结直肠癌
整合药理学平台
Mylabris
colorectal cancer
internet-based computation platform
