摘要
研究了水相三乙胺催化3,5-二烷基-4-硝基异噁唑与三氟甲基酮的亲核加成反应,以66%~99%的产率合成了一系列三氟甲基叔醇衍生物.通过脱水或氧化反应可有效的将目标产物转化为烯烃或羧酸类化合物.
The triethylamine catalyzed nucleophilic addition of 3,5-dialkyl-4-nitroisoxazoles to trifluoromethyl ketones on water has been realized affording trifluoromethyl tertiary alcohol derivatives in 66%~99% yields.The products were easily transformed to the resulting alkenes by dehydration or acids by oxidation.
作者
王晶晶
李峰
徐妍
王娟
武紫燕
杨成玉
刘澜涛
Wang Jingjing;Li Feng;Xu Yan;Wang Juan;Wu Ziyan;Yang Chengyu;Liu Lantao(Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 47600)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2018年第5期1155-1164,共10页
Chinese Journal of Organic Chemistry
基金
Project supported by the National Natural Sciences Foundation of China(Nos.21402116,21502111,21572126)
the Key Scientific and Technological Project of Henan Province(No.172102210099)
the Key Science Research of Education Committee in Henan Province(No.15A150072)~~
