摘要
探索了三氟甲基酰腙的N-烃基化反应,得到了一系列N-烃基取代的三氟甲基酰腙衍生物.其结构经1H NMR和13C NMR、HRMS等确证.该方法具有反应条件温和、产率高及操作简单等优点,为合成N-烃基取代的三氟甲基酰腙类化合物提供了一种简单高效的方法.
The N-alkylation reaction of trifluoromethylated acylhydrazones was investigated,and a series of N-alkyl trifluoromethyl acylhydrazones were afforded in good yield.Their structures were confirmed by 1H NMR,13C NMR and HRMS analysis.The strategy has advantages of simple and mild reaction conditions,wide scope of substrates and good yields.This protocol provides an efficient and new method for the synthesis of N-alkyl substituted trifluoromethyl acylhydrazones.
作者
杨金宇
黄丹凤
王克虎
王君姣
苏瀛鹏
邓周斌
杨天宇
胡雨来
Yang Jinyu;Huang Danfeng;Wang Kehu;Wang Junjiao;Su Yingpeng;Deng Zhoubin;Yang Tianyu;Hu Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2021年第5期2029-2037,共9页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21662030,22061037)资助项目.
关键词
三氟甲基酰腙
卤代烃
Α
Β-不饱和酯
N-烃基化
trifluoromethyl acylhydrazone
halohydrocarbon
α,β-unsaturated ester
N-alkylation
