摘要
探索了铟粉促进下,三氟乙醛甲基半缩醛或三氟甲基苯乙酮与酰肼和烯丙基溴的"一锅法"反应,高产率地得到了一系列三氟甲基高烯丙基酰肼类化合物.该方法使用价廉易得的三氟乙醛甲基半缩醛或三氟苯乙酮作为三氟甲基合成砌块,具有反应条件温和、产率高、操作简单等优点.
An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and allyl bro- mide promoted by indium powder is reported, and a series of trifluoromethylated homoallylic N-acylhydrazines were obtained with good to excellent yields. The features of this process include readily available starting materials as trifluoromethyl build- ing blocks, mild conditions and easy operation.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第4期925-935,共11页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.21262031
21462037)资助项目~~
关键词
一锅法
铟粉
三氟乙醛甲基半缩醛
三氟苯乙酮
酰肼
三氟甲基高烯丙基酰肼
one.pot
indium powder
trifluoroacetaldehyde methyl hemiacetal
trifluoroketones
arylacylhydrazines
trifluo-romethylated homoaUylic N-acylhydrazines
