摘要
目的探究转录因子7类似物2(transcription factor 7-like 2,TCF7L2)基因多态性与中国人群2型糖尿病(type 2 diabetes mellitus,T2DM)发病的相关性。方法检索PubMed、Web of Science、中国期刊全文数据库、万方数字化期刊全文数据库等数据库,检索时间到2017年7月。人选文献的质量评估采用文献质量评价量表(Newcastle-Ottawa scale,NOS),运用Stata 12.0软件,以OR值作为合并效应量指标,分别分析基因型、等位基因与T2DM的关联性。定量分析各研究间的异质性,计算I^2,并使用亚组分析方法探索异质性来源。同时采用敏感性分析评估结果的稳定性,并用Begg和Egger检验评估发表偏倚。结果共纳入文献41篇,病例和对照分别为16 981、27 334例。位点rs7901695的CC/CT基因型频率(OR=1.398,95%CI:1.072～1.822)或C等位基因频率(OR=1.270,95%CI:1.147～1.407)、位点rs12255372的AA/GA基因型频率(OR=1.275,95%CI:1.126～1.443)或A等位基因频率(OR=1.249,95%CI:1.120～1.393)以及位点rs7903146的TT/CT基因型频率(OR=1.747,95%CI:1.364～2.238)或T等位基因频率(OR=1.719,95%CI:1.366～2.164)在病例组与对照组之间差异均具有统计学意义(均有P<0.05)。结论 TCF7L2基因rs7901695、rs12255372、rs7903146位点的多态性与中国人群bT2DM发病的有关。
Objective To investigate the association between polymorphism of transcription factor 7-like 2 （TCFTL2） gene and incidence of type 2 diabetes mellitus （T2DM） in Chinese population. Methods The study on the polymorphism of TCFTL2 and T2DM were retrieved from PubMed, Web of science, Chinese journal full-text database, Wanfang digital journal full-text database and other databases. The search time was until July 2017. The quality of the selected articles was assessed using the Newcastle-Ottawa scale （NOS） quality evaluation table and stata 12. 0 software was used to conduct the meta analysis. The association of genotype, allele with type 2 diabetes was analyzed respectively using OR value as a combination effect index. 12 was calculated in order to quantitatively analyze the heterogeneity among the studies. Subgroup analysis was used in order to explore sources of heterogeneity. Sensitivity evaluation, Begg＇ s Test and Egger＇ s Test was used to assess the stability and the publication bias of the results. Results A total of 41 articles were screened（with 16 981 cases of T2DM and 27 334 healthy subjects）. The analysis showed that the frequency of CC/CT genotype frequency (OR = 1. 398, 95% CI： 1. 072-1. 822） or C allele frequency (OR = 1. 270, 95% CI： 1. 147-1. 407) of rs7901695, the frequency of AA/GA genotypes (OR = 1. 275, 95% CI： 1. 126-1. 443) or A allele (OR = 1. 249, 95% CI： 1. 120-1. 393） of rs12255372, and the frequency of TT/CT genotype (OR = 1. 747, 95% CI： 1. 364-2. 238） or T allele (OR = 1. 719, 95% CI：1. 366-2. 164） of rs7903146 had significant difference .between the T2DM group and the control group (all P 〈 0. 05). Conclusions The findings revealed that the Chinese population with TCF7L2 rs7901695, rs12255372 and rs7903146 gene polymorphism may be susceptible to T2DM.
作者
杨曼
汪清
洪翔
连大帅
殷玥琪
吴楠楠
王蓓
YANG Man;WANG Qing;HONG Xiang;LIAN Da-shuai;YIN Yue-qi;WU Nan-nan;WANG Bei(Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Nanjing 210009, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2018年第5期504-509,共6页
Chinese Journal of Disease Control & Prevention
基金
糖尿病的危险因素早期识别、早期诊断技术与切点研究(2016YFC1305700)
