摘要
目的考察常温水提、40℃水提、水煎煮对白芷总香豆素提取物的影响。方法分别采用乙醇回流提取和3种水提预处理方法得到提取物Ⅰ~Ⅳ,UV和HPLC法分别测定总香豆素、欧前胡素含有量,比较提取物粉体学性质和溶出度。结果 4种提取物中总香豆素含有量分别为3.98%、6.03%、6.81%、4.46%,欧前胡素含有量分别为0.633%、0.540%、0.465%、0.155%,休止角分别为48.455°、42.587°、42.689°、42.024°,堆密度分别为0.214、0.324、0.316、0.354 g/cm^3。提取物Ⅰ在100 min内的吸湿速率和平衡吸湿量高于其他3种提取物。各提取物在120 min内的累积溶出度均显著高于药材细粉。结论 3种水提预处理方法均可明显改善白芷总香豆素提取物的粉体学性质,并提高药材细粉的溶出度。
AIM To investigate the effects of aqueous extraction at normal temperature,40 ℃,and water boiling on total coumarins extract of Angelicae dahuricae Radix. METHODS For the extractsⅠ-Ⅳ obtained by ethanol reflux extraction and three aqueous extraction preprocessing methods,respectively,UV and HPLC were adopted in the content determination of total coumarins and imperatorin,then the powder properties and dissolution rates were compared. RESULTS The contents of total coumarins in four extracts were 3. 98%,6. 03%,6. 81%and 4. 46%,while those of imperatorin were 0. 633%,0. 540%,0. 465% and 0. 155%,respectively. The angles of repose were 48. 455°,42. 587°,42. 689° and 42. 024° with the bulk densities of 0. 214,0. 324,0. 316 and0. 354 g/cm^3,respectively. Within 100 min,extractⅠdemonstrated higher moisture adsorption rate and equilibrium moisture absorption content than the other three extracts. The accumulative dissolution rates of various extracts were much higher than that of medicinal material fine powder within 120 min. CONCLUSION All the three aqueous extraction preprocessing methods can obviously improve the powder properties of total coumarins extract of A. dahuricae Radix and increase the dissolution rate of medicinal material fine powder.
作者
常金花
李云
刘翠哲
CHANG Jin-hua;LI Yun;LIU Cui-zhe(Hebei Provincial Key Laboratory for Research and Development of Chinese Medicine,Chengde Medical College,Chengde 067000, Chin)
出处
《中成药》
CAS
CSCD
北大核心
2018年第5期1065-1069,共5页
Chinese Traditional Patent Medicine
基金
河北省高校重点学科建设项目(冀教高[2013]4)
关键词
白芷总香豆素提取物
水提取预处理方法
总香豆素
欧前胡素
粉体学性质
溶出度
total coumarns extract of Angelicae dahuricae Radii
aqueous extraction preprocessing methods
total coumarns
imperatorin
powder properties
dissolution rates
