摘要
肺纤维化是一种慢性进行性间质性肺部疾病,主要表现为大量成纤维细胞、肌成纤维细胞集聚,细胞外基质沉积.近年来,研究表明转化生长因子β1/Smad3通路在肺纤维化中有重要作用.microRNA-29是一种非编码单链小分子 RNA,同时是 Smad3下游靶基因,可调控转化生长因子β1信号通路.本文就microRNA-29在肺纤维化发生进程中的作用作一综述,为治疗肺纤维化找到新方向.
Pulmonary fibrosis is a chronic,progressive and interstitial lung disease.The main manifestations are the accumulation of fibroblasts,myofibroblasts and the deposition of extracellular matrix.Recent studies have shown that transforming growth factor-β1/Smad3 pathway plays an important role in pulmonary fibrosis.MicroRNA-29 is a non-coding single-stranded small molecule RNA and also a downstream target gene of Smad3,which regulates transforming growth factor-β1signaling pathway.This paper reviews the role of microRNA-29 in the process of pulmonary fibrosis and provides a new direction for the treatment of pulmonary fibrosis.
作者
张秀莉
邱静
李万成
Zhang Xiuli, Qiu Jing, Li Wancheng.(Department of Respiratory Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, Chin)
出处
《国际呼吸杂志》
2018年第8期627-630,共4页
International Journal of Respiration
