摘要
目的观察双歧杆菌三联活菌散对儿童轮状病毒性肠炎(RVE)患者肠道菌群和肠黏膜通透性的影响。方法选择2016年1月至2017年8月于丽水市中心医院儿科门诊治疗的RVE患儿94例,随机分为观察组和对照组各47例。两组患儿均予饮食调整、补液及纠正电解质紊乱和酸碱失衡等治疗。观察组患儿加用双歧杆菌三联活菌散1.0g/次,3次/d,温水冲服。观察两组患儿治疗前后肠道菌群(双歧杆菌、乳杆菌和大肠埃希菌)数量和肠黏膜通透性指标[内毒素(ETX)和D-乳酸]的变化,并比较其临床疗效。结果治疗72h后,观察组患儿双歧杆菌和乳杆菌数量明显上升,大肠埃希菌数量明显下降(P<0.05),而对照组治疗前后无明显变化(P>0.05)。治疗后观察组患儿双歧杆菌、乳杆菌数量较对照组更高,大肠埃希菌数量较对照组更低(P<0.05)。两组患儿治疗后血清ETX和D-乳酸水平均明显下降(P<0.05),且观察组下降幅度更大(P<0.05);同时观察组患儿总有效率高于对照组(χ2=4.11,P<0.05)。结论双歧杆菌三联活菌散治疗儿童RVE的疗效确切,其作用机制可能与其能增加双歧杆菌和乳杆菌等有益菌的数量,减少大肠埃希菌等致病菌的数量,改善患儿肠道微生态状况;并与其能降低肠黏膜通透性和减少肠液的分泌渗出相关。
Objective To observe the influence of Bifid Triple Viable Powder on intestinal flora and intestinal mucosal permeability of children with rotavirus enteritis.Methods 94 cases of rotavirus enteritis in Department of Paediatrics in Lishui Central hospital from January 2016 to August 2017 were selected and randomly divided into observation group（n=47）or control group（n=47）.The children in two groups were given the same basic treatment,including diet adjustment,fluid infusion,and adjustment of electrolyte disturbance and acid-base imbalance,while those in observation group were additionally given Bifid Triple Viable Powder 1.0 g t.i.d orally.The changes of the quantities of intestinal flora（Bifidobacteria,Lactobacilli and E.coli）and the indexes of intestinal mucosal permeability（ETX and D-lactic acid）in both groups were observed and compared before and after treatment,and the clinical efficacy was compared between two groups.Results After treatment,the quantities of Bifidobacteria and Lactobacilli were increased and that of E.coli were reduced in observation group（Ps〈0.05）,while no obvious changes were observed in control group（Ps〉0.05）.The quantities of Bifidobacteria and Lactobacilli in observation group were higher,while that of E.coli in observation group was lower than in control group after treatment（P〈0.05）.The levels of serum ETX and D-lactic acid in both groups were obviously lower than before（P〈0.05）,with the declining rate in observation group higher than that in control group（P〈0.05）.The total clinical efficiency rate in observation group was higher than that in control group（χ^2=4.11,P〈0.05）.Conclusion Bifid Triple Viable Powder has reliable curative effect on children with rotavirus enteritis,the mechanism of which may have close correlation with its effects of increasing the quantities of beneficial bacteria,reducing the quantity of pathogenic bacteria,improving intestinal microecology,decreasing intestinal mucosal permeability,repairing and protecti
作者
蔡海芳
CAI Haifang(Department of Paediatrics, Lishui Central Hospital, Lishui, Zhejiang 323000, Chin)
出处
《中国微生态学杂志》
CAS
CSCD
2018年第4期434-437,共4页
Chinese Journal of Microecology
