摘要
MicroRNAs(miRNAs)是一类内源性的、长度约为20~25个核苷酸的非编码单链小RNA分子,它能与mRNA的3’端非编码区(3’UTR)靶向结合,从而在转录或翻译水平上调控靶基因的表达。miR-204作为miRNAs的重要一员,参与细胞的生长发育、增殖、分化及凋亡等多个生物学过程。本文主要论述了miR-204在细胞增殖与分化过程中的作用及调控机制。
MicroRNAs（miRNAs）are a type of endogenous non-coding and single-stranded RNA molecules consisting of 20-25 nucleotides.It target to the 3＇UTR of the mRNA and regulate the expression of the target gene at the transcriptional or translational level.As an important member of miRNAs,miR-204 participated in many biological processes,such as cell growth,proliferation,differentiation and apoptosis.This article mainly discussed the role of miR-204 in cell proliferation and differentiation and its regulatory mechanism.
作者
唐琦
金云云
高佳阳
鱼婷
杨韩
雷初朝
蓝贤勇
陈宏
TANG Qi;JIN Yun-yun;GAO Jia-yang;YU Ting;YANG Han;LEI Chu-zhao;LAN Xian-yong;CHEN Hong(College of Animal Science and Technology,Northwest A＆F University,Yangling,Shaanxi,712100 China)
出处
《中国牛业科学》
2018年第2期70-74,共5页
China Cattle Science
基金
国家自然科学基金(面上项目)(No.31672400)
2017年西北农林科技大学大学生科创项目(No.201710712013)
国家肉牛牦牛产业技术体系(CARS-37)资助
关键词
miR-204
功能机制
增殖
分化
miR-204
function mechanism
proliferation
differentiation
