摘要
目的观察百令胶囊联合氯沙坦钾治疗慢性肾小球肾炎的临床疗效。方法选取长江航运总医院于2015年10月—2017年5月收治的112例慢性肾小球肾炎患者,随机分为对照组和治疗组,每组各56例。对照组口服氯沙坦钾片,50 mg/次,1次/d。治疗组在对照组的基础上口服百令胶囊,5粒/次,3次/d。两组患者持续治疗3个月。比较两组治疗前后的临床疗效,观察两组治疗前后肾功能、营养状态和血清Lkn-1和VEGF水平的变化情况。结果治疗后,对照组和治疗组的临床总有效率分别为76.79%和92.86%,两组比较差异具有统计学意义(P<0.05)。两组Scr、BUN、24 h尿蛋白定量水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05),且治疗后治疗组Scr、BUN、24 h尿蛋白定量水平均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。两组患者血清总蛋白和白蛋白含量均较治疗前显著升高,同组治疗前后比较差异具有统计学意义(P<0.05),且治疗组血清总蛋白和白蛋白含量均显著高于对照组,两组比较差异具有统计学意义(P<0.05)。两组血清Lkn-1和VEGF水平均较治疗前显著降低,同组治疗前后比较差异具有统计学意义(P<0.05),且治疗组血清Lkn-1和VEGF水平均显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论百令胶囊联合氯沙坦钾治疗慢性肾小球肾炎疗效显著,同时能明显改善患者营养状态,降低其血清Lkn-1和VEGF水平。
Objective To observe the clinical effect of Bailing Capsule combined with losartan potassium in treatment of chronic glomerulonephritis. Methods Patients（112 cases） with chronic glomerulonephritis in Yangtze River Shipping General Hospital from October 2015 to May 2017 were randomly divided into control and treatment groups. Each group had 56 cases. Patients in the control group were po administered with Losartan Potassium Tablets, 50 mg/time, once daily. Patients in the treatment group were po administered with Bailing Capsule on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 3 months. After treatment, the clinical efficacy were evaluated, renal function, state of nutrition, and Lkn-1 and VEGF levels in serum in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 76.79% and 92.86%, respectively, and there were differences between two groups（P＜0.05）. Scr, BUN, and 24 h urine protein quantity levels in two groups were significantly decreased, and the difference was statistically significant in the same group（P＜0.05）. And these levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P＜0.05）. Total protein and albumin levels in serum in two groups were significantly increased, and the difference was statistically significant in the same group（P＜0.05）. And these levels were higher than those in the control group, with significant difference between two groups（P＜0.05）. Lkn-1 and VEGF in two groups were significantly decreased, and the difference was statistically significant in the same group（P＜0.05）. And Lkn-1 and VEGF levels were significantly lower than those in the control group, with significant difference between two groups（P＜0.05）. Conclusion Bailing Capsule combined with losartan potassium has good effect in treatment of chronic glomeruloneph
作者
何艳
郭爱莉
陶晓岚
HE Yan;GUO Ai-li;TAO Xiao-lan(Department of Nephrology, Yangtze River Shipping General Hospital, Wuhan 430010, China)
出处
《现代药物与临床》
CAS
2018年第4期903-907,共5页
Drugs & Clinic
