摘要
以2,6-吡啶二甲酸、乙二胺、水杨醛等为原料,合成了多齿Schiff碱仲胺配体N,N＇-双（2-羟基苯甲基仲胺基乙基）-2,6-吡啶二甲酰胺（L）,进一步将L与Cu2＋、Zn2＋、Pb2＋、Mn2＋、Co2＋等过渡金属配位,合成了5个过渡金属配合物（A-Cu、B-Zn、C-Pb、D-Mn、E-Co）。通过元素分析、红外光谱、紫外光谱及核磁共振氢谱等对配体及配合物进行了表征和结构推测;并采取微量稀释法考察了它们对大肠杆菌的抑菌活性。结果表明：L、E-Co及B-Zn的IC50分别为50.68、42.83、47.74μmol/L;可见,当配体与Co2＋和Zn2＋配位后对大肠杆菌抑菌效果明显增强。
The linear multidentate Schiff base amine ligand, N,N＇-bis（2-dihydroxyphenyl-amidoethyl）-2,6 -pyridinedicarboxylic diamide （L）, was synthesized from 2,6-pyridinedicarboxylic acid, ethylenediamine and salicylaldehyde. Subsequently, the coordination of L with Cu^2＋, Zn^2＋, Pb^2＋, Mn^2＋, and Co^2＋ formed five new transition metals complexes（A-Cu, B-Zn, C-Pb, D-Mn, E-Co）.The ligand and its complexes were characterized by elemental analysis, FTIR, UV-vis spectra and 1HNMR. The rational structures of complexes were speculated.Furthermore, their antibacterial activities on Escherichia coli （E. coli） were evaluated by micro-dilution. The IC50 value of L, E-Co and B-Zn were 50.68, 42.83 and 47.74 umol/L, respectively. The results indicated that complexes E-Co and B-Zn exhibited good inhibitory effect on Escherichia colc.
作者
蔡丽华
叶亚娟
锁进猛
范康俊
姜凌
CAI Li-hua, YE Ya-juan, SUO Jin-meng, FAN Kang-jun, JIANG Ling(Environmental and Biological Engineering College, Wuhan Technology and Business University, Wuhan 430065, Hubei, China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2018年第5期808-812,共5页
Fine Chemicals
基金
湖北省教育厅科研计划基金(B2016338)
湖北省大学生创新创业训练计划(201613242014)~~
