摘要
以N,N′-双(2-胺基乙基)-2,6-吡啶二甲酰胺(Ⅰa)为中间体、芳香醛为主要原料合成了芳香醛Schiff碱(Ⅱa,b,c),在NaBH4的作用下,将Ⅱa,b,c还原成Schiff碱仲胺(Ⅲa,b,c),用红外,氢核磁共振,质谱等分析方法对样品的结构进行表征,并采取试管稀释法初步研究了Ⅱa及Ⅲa对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌的抑菌活性.结果表明:Ⅱa及Ⅲa对上述细菌的生长均有一定的抑制作用,且对大肠杆菌抑菌效果较明显,而Ⅲa的抑菌效果明显优于Ⅱa的抑菌效果.
The Schiff bases（Ⅱa,b,c）were synthesized form aromatic aldehyde and N,N′-bis（2-aminoethyl）-2,6-pyridinedicarboxylic diamide（Ⅰa）.They were reduced to be secondary amines（Ⅲa,b,c）with NaBH4,which structures were characterized by IR,1 H NMR,MR.The inhibitory activities of compoundⅡa andⅢa on Escherichia coli,Staphylococcus aureus and Bacillus subtilis were primarily studied through the tube dilution method.The results appear that both Ⅱa andⅢa show good inhibitory effect on above-mentioned bacteria,especially on E.coli,andⅢa is more powerful than Ⅱa.
出处
《武汉大学学报（理学版）》
CAS
CSCD
北大核心
2017年第3期241-245,共5页
Journal of Wuhan University:Natural Science Edition
基金
湖北省教育厅科研计划基金资助项目(B2016338)
关键词
吡啶双酰胺基
Schiff碱仲胺
合成
抗菌活性
pyridinedicarboxylic diamide
Schiff bases amine
synthesize
antibacterial activity
