摘要
目的研究原发于直肠及肺神经内分泌肿瘤的临床病理特征,明确影响患者预后的因素。方法收集90例原发于直肠及肺神经的内分泌肿瘤患者的临床病理特征资料,其中原发于直肠的神经内分泌肿瘤患者43例,原发于肺部的神经内分泌肿瘤患者47例,通过对90例患者临床病理特征进行分析,结合预后的随访,明确影响患者预后的因素。结果原发于直肠神经内分泌肿瘤患者43例,其中男性患者25例,女性患者18例;经过诊断,典型类癌32例,不典型类癌6例,小细胞癌5例;其中有9例发生了淋巴结转移;39例患者进行了根治性手术,4例行姑息放化疗。原发于肺神经内分泌肿瘤患者47例,其中男性患者34例,女性患者13例;其中肿瘤位于左肺的15例,右肺的25例,中央型7例;发生淋巴结转移12例。对原发于直肠神经内分泌肿瘤患者进行单因素分析,发现患者年龄、病理类型、肿瘤大小、TNM分期、淋巴结转移影响患者的预后生存,差异有统计学意义(P<0.05);对原发于肺神经内分泌肿瘤患者进行单因素分析,发现年龄、肿瘤大小、TNM分期、病理分类、淋巴结转移间数据差异有统计学意义(P<0.05)。结论原发于直肠及肺神经内分泌肿瘤患者预后总体较好,但不同的病理特征预后差别较大,一旦发生淋巴结转移,生存率极低。
Objective To study the clinical and pathological features of primary and pulmonary neuroendocrine tumors,and to determine the prognostic factors. Methods The clinical and pathological features of 90 patients with endocrine tumors of the rectum and pulmonary nerves were collected. Among them,43 patients with neuroendocrine tumors were found in the rectum and 47 patients with neuroendocrine tumors in the lungs. The clinicopathological features of the patients were analyzed,and the follow-up of the prognosis was used to determine the prognostic factors. Results 43 cases of patients with primary rectal neuroendocrine tumors,including 25 cases of male patients and 18 female patients;after diagnosis,32 cases of typical carcinoid,atypical carcinoid in 6 cases,5 cases of small cell carcinoma;9 cases had lymph node metastasis;39 cases underwent radical surgery,4 cases underwent palliative chemotherapy. There were 47 cases of pulmonary neuroendocrine tumors,including 34 male patients and13 female patients. The tumors were located in 15 cases of the left lung,25 cases of the right lung,7 cases of central type,and 12 cases of lymph node metastasis. Patients with primary rectal neuroendocrine tumors were analyzed by single factor analysis,found that age,pathological characteristics,tumor size,TNM stage,lymph node metastasis effecting survival of patients,the difference was statistically significant（ P〈0. 05）;Patients with primary pulmonary neuroendocrine tumors were analyzed by single factor analysis,found to have statistical difference between age,tumor size,TNM stage,pathological classification,and lymph node metastasis（ P〈0. 05）. Conclusion The prognosis of patients with primary and pulmonary neuroendocrine tumors is generally better,but the prognosis of different pathological features is different. In the event of lymph node metastasis,the survival rate is very low.
作者
王建瑞
WANG Jianrui(Zhumadian Hospital of Traditional Chinese Medicine,Zhumadian,46300)
出处
《实用癌症杂志》
2018年第5期861-864,共4页
The Practical Journal of Cancer
关键词
直肠
肺
神经内分泌肿瘤
病理特征
预后
Rectum
Lung
Neuroendocrine tumors
Pathological features
Prognosis
