摘要
目的探讨胃混合性腺神经内分泌癌（MANEC）的临床病理特征。方法选择2013年1月至2016年1月确诊的胃腺癌患者2 628例，从中选取经免疫组化证实的胃混合性腺神经内分泌癌4例，复习所有病例的存档切片，对原有免疫组化切片进行突触素（Syn）、神经细胞粘附分子（CD56）、神经元特异性烯醇化酶（NSE）、嗜铬蛋白（CgA）、增殖细胞核抗原Ki-67、细胞角蛋白（cytokeratin, AE1/AE3）判读。分析MANEC患者的临床病理特征。结果胃MANEC临床表现为上腹不适等非特异性症状，光镜下可见腺癌和神经内分泌癌两种成分，且两种成分均〉30%。腺癌成分表达AE1/AE3，神经内分泌癌成分不同程度的表达AE1/AE3、CD56、Syn、NSE、CgA；4例Ki-67阳性指数均〉70%。结论胃MANEC的确诊主要依赖于组织学形态和免疫组化标记。
ObjectiveTo investigate the clinical and pathological features of gastric mixed adenoneuroendocrine carcinoma（MANEC） .MethodsFrom January 2013 to January 2016, 2 628 cases were diagnosed with gastric adenocarcinoma, from which to choose four cases of mixed adenoneuroendocrine carcinoma by immunohistochemistry, and all slides in the files were reviewed.The interpretation of Syn, CgA, CD56, NSE, AE1/AE3 and Ki-67 were detected by immunohistochemistry. The clinical symptoms, pathological, characteristics, treatment and prognosis were retrospectively analyzed.ResultsThe main clinical manifestations were non-specific symptoms, such as abdominal discomfort.MANEC was composited by adenocarcinoma and neuroendocrine neoplasm, each one comprising at least 30% of the tumor. AE1/AE3 was expressed in adenocarcinoma components. AE1/AE3, Syn, CD56, NSE and CgA were expressed in neuroendocrine components in different degrees. Ki-67 index was 〉70% in all cases.ConclusionsThe diagnosis of MANEC is rested on histology and immunohistochemistry and the prognosis of MANEC is worse than that of the common adenocarcinoma.
作者
雷瑞雪
苗兰芳
郭梅
Lei Ruixue Miao Lanfang Guo Mei(Department of Pathology,Anyang Tumor Hospital, Anyang 455000, Chin)
出处
《中国实用医刊》
2017年第1期4-6,F0004,共4页
Chinese Journal of Practical Medicine
关键词
混合性腺神经内分泌癌
免疫组化
胃
Mixed adenoneuroendocrine carcinoma
Immunohistochemistry
Stomach
