摘要
目的:探讨芪红汤联合美托洛尔对冠心病心绞痛气虚血瘀型患者血浆内皮素(ET)、超敏C反应蛋白(hs-CRP)、氨基末端B型脑利钠肽原(NT-proBNP)水平的影响。方法:选择我院2014年6月~2016年6月收治的98例冠心病心绞痛气虚血瘀型患者,按治疗方式分为对照组与研究组,每组49例。对照组选用美托络尔治疗,研究组在美托络尔基础上联合芪红汤治疗,两组均持续治疗1个月。观察和比较两组的临床疗效,治疗前后症状积分、血浆ET、hs-CRP、NT-proBNP、左室射血分数(LVEF)、6 min步行试验、心绞痛持续时间、发作频率及心脏不良事件的发生情况。结果:治疗后,研究组总有效率显著高于对照组(P<0.05),两组症状积分、ET、hs-CRP、NT-proBNP、心绞痛持续时间、发作频率均较治疗前显著降低(P<0.05),且研究组以上指标均显著低于对照组(P<0.05);两组LVEF、6-WMT均较治疗前上升(P<0.05),且研究组以上指标均明显高于对照组(P<0.05)。研究组心脏不良事件发生率显著低于对照组(P<0.05)。结论:芪红汤联合美托络尔治疗冠心病心绞痛气虚血瘀型患者的临床效果肯定,能够有效降低患者血浆ET、hs-CRP、NT-proBNP水平。
Objective： To research the influence of Qihong Tang combined with metoprolol on the plasma endothelin （ET）, hypersensitive c-reactive protein （hs-CRP） and amino terminal b-type brain natriuretic peptide （NT-proBNP） levels of patients with coronary heart disease angina pectoris qi deficiency and blood stasis type. Methods： 98 cases of patients with coronary heart disease angina pectoris Qi deficiency and blood stasis type from June 2014 to June 2016 were selected and divided into the control group and the research group according to the treatment mode with 49 cases in each group. The control group was treated with metoprolol, while the research group was treated with qihong tang based on metoprolol, both groups were treated for 1 month. The clinical curative effect, symptom score, plasma ET, hs-CRP, NT-proBNP levels, left ventricular ejection fraction （LVEF）, 6 min walk test, angina, duration, attack frequency before and after the treatment and the incidence of cardiac adverse events were observed and compared between two groups. Results： After treatment, the total effective rate of research group was significantly higher than that of the control group （P〈0.05）. The symptom score, plasma ET, hs CRP, NT-proBNP levels, LVEF, symptom integral, 6 min walk test, duration of angina pectoris, seizure frequency of both groups were all significantly reduced than those before treatment, and the above indicators of research group were significantly lower than those of the control group （P〈0.05）; the LVEF, 6-WMT of both group were rised, and the above indicators of research group were significantly higher than those of the control group （P〈0.05）. The incidence of cardiac adverse events of research group was significantly lower than that of the control group （P〈0.05）. Conclusion： Qihong Tang combined metoprolol was effective in the treatment of patients with Coronary heart disease angina pectoris Qi deficiency and blood stasis type,Qihong Tang combined metoprolol, the effect of w
作者
王媛
晏林
吴昊澎
赵昱博
常伟
WANG Yuan1, YAN Lin2, WU Hao-peng2, ZHAO Yu-bo2, CHANG Wei2(1 Department of internal medicine, the Central Hospital of Shenyang Medical College, Shenyang, Liaoning, 110000, China; 2 Shenyang Medical College, Shenyang, Liaoning, 110034, Chin)
出处
《现代生物医学进展》
CAS
2018年第6期1129-1132,1039,共5页
Progress in Modern Biomedicine
基金
辽宁省自然科学基金项目(2011K14326)
沈阳市社会科学研究课题项目(sysk2017-19-01)
关键词
冠心病心绞痛
气虚血瘀型
芪红汤
美托洛尔
内皮素
超敏C反应蛋白
氨基末端B型脑利钠肽原
Coronary heart disease angina pectoris
Breath deficiency and blood stasis
Qihong decoction
Metoprolol
Endothelin
Hypersensitive c-reactive protein
Amino terminal b-type brain natriuretic peptide
